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Nelson K. S. Khoo
Researcher at University of Western Ontario
Publications - 14
Citations - 1159
Nelson K. S. Khoo is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Trophoblast & Transforming growth factor. The author has an hindex of 9, co-authored 14 publications receiving 1079 citations. Previous affiliations of Nelson K. S. Khoo include Queen's University.
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Journal ArticleDOI
Establishment and Characterization of First Trimester Human Trophoblast Cells with Extended Lifespan
Charles H. Graham,Teresa S. Hawley,Robert C. Hawley,John Macdougall,Robert S. Kerbel,Nelson K. S. Khoo,Peeyush K. Lala +6 more
TL;DR: Apart from their ability to sustain prolonged growth in culture, the transfected HTR-8/SVneo cells share a number of phenotypic properties with the parental trophoblast cells, which may prove to be an important tool for the study of placental function and/or tumor progression.
Journal ArticleDOI
SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. I. Mechanisms responsible for hyperinvasivess and resistance to anti-invasive action of TGFβ
Nelson K. S. Khoo,John F. Bechberger,Trevor G. Shepherd,Shari L. Bond,Keith R. McCrae,G. Scot Hamilton,Peeyush K. Lala +6 more
TL;DR: RSVT‐2 and RSVT2/C cell lines were hyperproliferative and hyperinvasive when compared with the parental HTR8 cell line, and resistance to the anti‐invasive action of TGFβ was explained by the failure of T GFβ to upregulate TIMPs and PAI‐1, in contrast to the TGF β‐induced upregulation noted in parental H TR8 cells.
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Immunotherapy of mammary adenocarcinoma metastases in C3H/HeN mice with chronic administration of cyclo-oxygenase inhibitors alone or in combination with IL-2
TL;DR: Ibu proved to be an excellent substitute for Indo in preventing metastasis and NK cell activation when given alone, and also in ameliorating established metastases and activating lymphokine-activated killer cells when combined with IL-2.
Journal ArticleDOI
SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. II. Changes in gap junctional intercellular communication.
Nelson K. S. Khoo,Yuchun Zhang,John F. Bechberger,Shari L. Bond,Kathleen O. Hum,Peeyush K. Lala +5 more
TL;DR: It is suggested that downregulation of connexins with the resultant impairment in GJIC is an early event in tumor progression, as observed in the premalignant SV40 Tag transformants.
Journal ArticleDOI
Role of transforming growth factor-α (TGFα) and epidermal growth factor (EGF) on proliferation and invasion by first trimester human trophoblast
Jeffrey J. Lysiak,Ian H. Connelly,Nelson K. S. Khoo,William G. Stetler-Stevenson,Peeyush K. Lala +4 more
TL;DR: The studies reveal that the two important biological processes, e.g., trophoblast proliferation and invasion required for placental development are not necessarily linked.