Ngon T. Nguyen

TL;DR: These studies show that epithelial-derived laminin-511 is a critical early signal that directs ciliary function and DP maintenance as a requirement for hair follicle downgrowth.

TL;DR: In this paper, retroviral vectors were constructed containing long terminal repeat-driven full-length and epitope-tagged COL7A1 cDNA and evaluated for durability of type VII collagen expression and function in RDEB skin tissue regenerated on immune-deficient mice.

TL;DR: New data provides additional data to support the clinically meaningful benefit of treating chronic RDEB wounds with ex vivo, C7 gene-corrected autologous cell therapy and promoted wound healing that was associated with improved patient-reported outcomes.

TL;DR: It is found that individual domains (VI and V-III) on the laminin-332 beta3 chain provide distinct and highly divergent cell adhesion and tumor-promoting functions, and the uncoupling of stable adhesion from tumor progression in these studies suggests that laminIn-332/collagen VII interaction promotes epidermal carcinogenesis through signaling rather than adhesion.

TL;DR: Canine MMP, like its human counterpart, exhibits distinctive clinical signs and histopathological lesions, yet circulating autoantibodies target different antigenic epitopes, which could prove useful for studies on the pathogenesis or therapy of this human disease.