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Nicholas C. Bolden
Researcher at University of Maryland, Baltimore County
Publications - 2
Citations - 282
Nicholas C. Bolden is an academic researcher from University of Maryland, Baltimore County. The author has contributed to research in topics: RNA & Genome. The author has an hindex of 2, co-authored 2 publications receiving 228 citations.
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Journal ArticleDOI
Structure of the HIV-1 RNA packaging signal
Sarah C. Keane,Xiao Heng,Kun Lu,Siarhei Kharytonchyk,Venkateswaran Ramakrishnan,Gregory Carter,Shawn Barton,Azra Hosic,Alyssa Florwick,Justin Santos,Nicholas C. Bolden,Sayo McCowin,David A. Case,Bruce A. Johnson,Marco Salemi,Alice Telesnitsky,Michael F. Summers +16 more
TL;DR: The structure shows how the 5′ leader binds to the HIV protein that directs packaging, how unspliced dimeric genomes are selected for packaging, and how translation is suppressed when the genome dimerizes.
Journal ArticleDOI
Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome.
Siarhei Kharytonchyk,Sarah Monti,Philip J. Smaldino,Verna Van,Nicholas C. Bolden,Joshua D. Brown,Emily Russo,Canessa Swanson,Alex Shuey,Alice Telesnitsky,Michael F. Summers +10 more
TL;DR: It is shown that multiple transcripts with different functions are generated in infected cells, a consequence of heterogeneous transcriptional start site usage, and that viral RNAs containing a single 5′ capped guanosine (Cap1G) are specifically selected for packaging in virions.