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Bruce A. Johnson
Researcher at City University of New York
Publications - 33
Citations - 5809
Bruce A. Johnson is an academic researcher from City University of New York. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Chemical shift. The author has an hindex of 21, co-authored 33 publications receiving 5514 citations. Previous affiliations of Bruce A. Johnson include Merck & Co. & Yale University.
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Journal ArticleDOI
NMR View: A computer program for the visualization and analysis of NMR data.
TL;DR: NMR View provides structure analysis features and data transfer to and from structure generation programs, allowing for a tight coupling between spectral analysis and structure generation.
Book ChapterDOI
Using NMRView to Visualize and Analyze the NMR Spectra of Macromolecules
TL;DR: Nuclear magnetic resonance (NMR) experiments on macromolecules can generate a tremendous amount of data that must be analyzed and correlated to generate conclusions about the structure and dynamics of the molecular system.
Journal ArticleDOI
Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.
Joel Berger,Ann Petro,Karen L. MacNaul,Linda J. Kelly,Bei B. Zhang,Karen Richards,Alex Elbrecht,Bruce A. Johnson,Gaochao Zhou,Thomas W. Doebber,Chhabi Biswas,Mona Parikh,Neelam Sharma,Michael R. Tanen,G. Marie Thompson,John Ventre,Alan D. Adams,Ralph T. Mosley,Richard S. Surwit,David E. Moller +19 more
TL;DR: It is established that novel selective PPARgamma modulators can produce altered receptor conformational stability leading to distinctive gene expression profiles, reduced adipogenic cellular effects, and potentially improved in vivo biological responses.
Journal ArticleDOI
Structure of the HIV-1 RNA packaging signal
Sarah C. Keane,Xiao Heng,Kun Lu,Siarhei Kharytonchyk,Venkateswaran Ramakrishnan,Gregory Carter,Shawn Barton,Azra Hosic,Alyssa Florwick,Justin Santos,Nicholas C. Bolden,Sayo McCowin,David A. Case,Bruce A. Johnson,Marco Salemi,Alice Telesnitsky,Michael F. Summers +16 more
TL;DR: The structure shows how the 5′ leader binds to the HIV protein that directs packaging, how unspliced dimeric genomes are selected for packaging, and how translation is suppressed when the genome dimerizes.
Journal ArticleDOI
Ligand-induced stabilization of PPARγ monitored by NMR spectroscopy: implications for nuclear receptor activation
TL;DR: Activation of this nuclear receptor is a result of a population shift of a dynamic ensemble of conformations, rather than a two-state switch from an inactive to an active conformation.