N
Nicholas J. Robinson
Researcher at University of Oxford
Publications - 4
Citations - 1343
Nicholas J. Robinson is an academic researcher from University of Oxford. The author has contributed to research in topics: IL-2 receptor & ZAP70. The author has an hindex of 4, co-authored 4 publications receiving 1278 citations.
Papers
More filters
Journal Article
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
Holm H. Uhlig,Brent S. McKenzie,S Hue,Claire Thompson,Barbara Joyce-Shaikh,Nicholas J. Robinson,Sofia Buonocore,Daniel J. Cua,Fiona Powrie +8 more
TL;DR: The experiments identified IL-23 as an effector cytokine within the innate intestinal immune system and suggests that it may make a more specific target for the treatment of IBD.
Journal ArticleDOI
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.
Simon Read,Rebecca J. Greenwald,Ana Izcue,Nicholas J. Robinson,Didier A. Mandelbrot,Loise M. Francisco,Arlene H. Sharpe,Fiona Powrie +7 more
TL;DR: Direct evidence that CTLA-4 has a specific, nonredundant role in the function of normal TR is provided, as such a strategy will not only boost effector T cell responses, but might also break TR-mediated self-tolerance.
Journal ArticleDOI
Regulatory T cells and intestinal homeostasis
Janine L. Coombes,Nicholas J. Robinson,Kevin J. Maloy,Holm H. Uhlig,Holm H. Uhlig,Fiona Powrie +5 more
TL;DR: Murine models of inflammatory bowel disease (IBD) are useful tools for the study of the pathogenesis and regulation of intestinal inflammation, and enhancement of regulatory T-cell activity may be useful to control autoreactive T‐cell responses and inhibit harmful inflammatory diseases such as asthma and IBD.
Journal ArticleDOI
Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.
Jane E. Willoughby,Patrick Costello,Robert H. Nicolas,Nicholas J. Robinson,Gordon Stamp,Fiona Powrie,Richard Treisman +6 more
TL;DR: The signaling requirements for development of T Reg cells in the thymus are distinct from those required for “conventional” T cell positive selection, and ERK signaling to SAP-1 is not required for the suppressive activity of Treg cells.