N
Nicholas R. Conley
Researcher at Stanford University
Publications - 31
Citations - 1404
Nicholas R. Conley is an academic researcher from Stanford University. The author has contributed to research in topics: Fluorophore & Internal medicine. The author has an hindex of 16, co-authored 28 publications receiving 1297 citations. Previous affiliations of Nicholas R. Conley include Lynn University & University of Texas at Austin.
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Journal ArticleDOI
Toward Nanometer-Scale Optical Photolithography: Utilizing the Near-Field of Bowtie Optical Nanoantennas
TL;DR: Optically resonant metallic bowtie nanoantennas are utilized as fabrication tools for the first time, resulting in the production of polymer resist nanostructures <30 nm in diameter at record low incident multiphoton energy densities.
Journal ArticleDOI
A photoactivatable push-pull fluorophore for single-molecule imaging in live cells.
Samuel J. Lord,Nicholas R. Conley,Hsiao-lu D. Lee,Reichel Samuel,Na Liu,Robert J. Twieg,W. E. Moerner +6 more
TL;DR: A red-emitting dicyanomethylenedihydrofuran push-pull fluorophore is reengineered so that it is dark until photoactivated with a short burst of low-intensity violet light, which provides a new class of bright photoactivatable fluorophores needed for super-resolution imaging schemes that require active control of single molecule emission.
Journal ArticleDOI
A Selenium Analogue of Firefly D-Luciferin with Red-Shifted Bioluminescence Emission†
TL;DR: A selenium analogue of amino-D-luciferin is synthesized and shown to be a competent substrate for the firefly luciferase enzyme, which has a red-shifted bioluminescence emission maximum at 600 nm and is suitable for biolumscence imaging studies in living subjects.
Journal ArticleDOI
DCDHF Fluorophores for Single-Molecule Imaging in Cells
Samuel J. Lord,Nicholas R. Conley,Hsiao-lu D. Lee,Stefanie Y. Nishimura,Andrea K. Pomerantz,Katherine A. Willets,Zhikuan Lu,Hui Wang,Na Liu,Reichel Samuel,Ryan L. Weber,Alexander N. Semyonov,Meng He,Robert J. Twieg,W. E. Moerner +14 more
TL;DR: A red-emitting DCDHF fluorophore is reengineered so that it is dark until photoactivated with a short burst of low-intensity violet light, providing a new class of bright photoactivatable small-molecule fluorophores, which are needed for super-resolution imaging schemes that require active control of single-Molecule emission.
Journal ArticleDOI
Azido Push−Pull Fluorogens Photoactivate to Produce Bright Fluorescent Labels†
Samuel J. Lord,Hsiao-lu D. Lee,Reichel Samuel,Ryan L. Weber,Na Liu,Nicholas R. Conley,Michael A. Thompson,Robert J. Twieg,W. E. Moerner +8 more
TL;DR: It is demonstrated that the azide-to-amine photoactivation process is generally applicable to a variety of push-pull chromophores, and the photophysical parameters including photoconversion quantum yield, photostability, and turn-on ratio are characterized.