N
Nicholas V. Hud
Researcher at Georgia Institute of Technology
Publications - 166
Citations - 9990
Nicholas V. Hud is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: RNA & Nucleic acid. The author has an hindex of 56, co-authored 159 publications receiving 8793 citations. Previous affiliations of Nicholas V. Hud include Lawrence Livermore National Laboratory & Georgia Tech Research Institute.
Papers
More filters
Journal ArticleDOI
DNA-templated Ag nanocluster formation.
TL;DR: Fluorescence, absorption, mass, and NMR spectra all indicate that multiple species are present, but that their creation is both nucleotide- and time-dependent, and that the nanoclusters are associated with the chiral ss-DNA template.
Journal ArticleDOI
The Selectivity for K+ versus Na+ in DNA Quadruplexes Is Dominated by Relative Free Energies of Hydration: A Thermodynamic Analysis by 1H NMR†
TL;DR: Analysis of competition between Na+ and K+ for coordination by G quartets using the oligonucleotide d(G3T4G3) as a model system indicates that at least two K+ are coordinated by the three quartets of the dimeric molecule, and perfect fits of the data are obtained for two Na+ being displaced by two K+.
Journal ArticleDOI
Cryoelectron microscopy of lambda phage DNA condensates in vitreous ice: the fine structure of DNA toroids.
TL;DR: Simulated transmission electron microscopy images of three-dimensional model toroids generated with perfect hexagonal DNA packing throughout faithfully reproduce most features observed in cryoelectron micrographs of actual toroids.
Journal ArticleDOI
The effect of sodium, potassium and ammonium ions on the conformation of the dimeric quadruplex formed by the Oxytricha nova telomere repeat oligonucleotide d(G 4 T 4 G 4 )
TL;DR: Results from further experiments using a variety of counterions reveal the same topology and loop conformation as in the K(+)form and allow the direct localization of three central ions in the stack of quartets and further show that there are no specific NH(4)(+)binding sites in the T(4)loop.
Journal ArticleDOI
Ester‐Mediated Amide Bond Formation Driven by Wet–Dry Cycles: A Possible Path to Polypeptides on the Prebiotic Earth
Jay G. Forsythe,Sheng Sheng Yu,Irena Mamajanov,Martha A. Grover,Ramanarayanan Krishnamurthy,Facundo M. Fernández,Nicholas V. Hud +6 more
TL;DR: A prebiotically plausible mechanism for peptide (amide) bond formation that is enabled by α-hydroxy acids is demonstrated, which supports a long-standing hypothesis that peptides might have arisen from ester-based precursors.