Nicola Silvestris

TL;DR: The triplet FOLFOXIRI showed improved outcomes for patients with metastatic colorectal cancer, compared with FOLFIRI (fluorouracil, leucovorin, and irinotecan) plus bevacizumab, but the actual benefit of the upfront exposure to the three cytotoxic drugs compared with a preplanned sequential strategy of doublets was not clear.

TL;DR: The current and possibly future applications of blood-based liquid biopsy in oncology, its advantages and its limitations in clinical practice are discussed, specifically focused on its role as a tool to capture tumor heterogeneity in metastatic cancer patients.

TL;DR: It is suggested that hospital use is not necessarily a sign of inappropriately aggressive care: inpatient care is probably an unavoidable step in the cancer trajectory and optimization of inpatient supportive procedures should be a specific task of modern medical oncology.

TL;DR: Both tumour models exposed to PALM rich in H2O2 showed a reduction in proliferation and an increase in calreticulin exposure and ATP release, suggesting the potential use of activated media as an inducer of immunogenic cell death via activation of the innate immune system.

TL;DR: This study illustrates the burden of bone metastases from CRC and supports the use of zoledronic acid in this setting and produced a trend toward improved overall survival versus no zoledronics acid.