Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study
Daniele Santini,Marco Tampellini,Bruno Vincenzi,Toni Ibrahim,Cinzia Ortega,Vladimir Virzì,Nicola Silvestris,Rossana Berardi,Cristina Masini,N. Calipari,Davide Ottaviani,Vincenzo Catalano,Giuseppe Badalamenti,R. Giannicola,Francesco Fabbri,Olga Venditti,Maria Elisabetta Fratto,Calogero Mazzara,Tiziana Latiano,Federica Bertolini,Fausto Petrelli,Azzurra Ottone,Cinzia Caroti,Lisa Salvatore,Alfredo Falcone,Paolo Giordani,Raffaele Addeo,Massimo Aglietta,Stefano Cascinu,Sandro Barni,Evaristo Maiello,Giuseppe Tonini +31 more
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This study illustrates the burden of bone metastases from CRC and supports the use of zoledronic acid in this setting and produced a trend toward improved overall survival versus no zoledronics acid.About:
This article is published in Annals of Oncology.The article was published on 2012-01-04 and is currently open access. It has received 109 citations till now. The article focuses on the topics: Bone metastasis & Zoledronic acid.read more
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The ASCRS Textbook of Colon and Rectal Surgery
Scott R. Steele,Tracy L. Hull,Thomas E. Read,Theodore J. Saclarides,Anthony J. Senagore,Charles B. Whitlow +5 more
TL;DR: The third edition of this book as mentioned in this paper provides a completely revised and updated new version of this unique, modern, practical text that covers the strategic evaluation, specific approaches, and detailed management techniques utilized by expert colorectal surgeons caring for patients with complex problems.
Journal ArticleDOI
Colorectal cancer: Metastases to a single organ
TL;DR: The disease characteristics, management approaches and prognosis based on the metastatic disease site in patients with CRC with metastases to a single organ are reviewed.
Journal ArticleDOI
Emerging tumor spheroids technologies for 3D in vitro cancer modeling.
Tânia Rodrigues,Banani Kundu,Joana Silva-Correia,Subhas C. Kundu,Joaquim M. Oliveira,Rui L. Reis,Vitor M. Correlo +6 more
TL;DR: Relationships between current models and their possible exploitation in clinical success is explored with the highlight of existing challenges in defining therapeutic targets and screening of drug efficacy.
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Incidence of bone metastases and survival after a diagnosis of bone metastases in breast cancer patients.
Mark Harries,Aliki Taylor,Lars Holmberg,Olorunsola F. Agbaje,Hans Garmo,S. Kabilan,Arnie Purushotham +6 more
TL;DR: Investigation of incidence and survival of bone metastases in women treated at Guy's Hospital, London 1976-2006 and followed until end 2010 found a trend for decreased survival for patients who developed visceral metastases early, and proportionately fewer patients in this group.
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Comparison of hybrid FDG PET/MRI compared with PET/CT in colorectal cancer staging and restaging: a pilot study
Raj Mohan Paspulati,Sasan Partovi,Karin A. Herrmann,Smitha S. Krishnamurthi,Conor P. Delaney,Nghi Nguyen +5 more
TL;DR: It is expected that PET/MRI would yield higher diagnostic accuracy than PET/CT considering the high soft tissue contrast provided by MRI compared with CT, but larger studies are necessary to fully assess the benefit of PET/ MRI in colorectal cancer.
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Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
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Cancer statistics, 2010
TL;DR: The American Cancer Society as mentioned in this paper estimated the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data regarding cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from National Center for Health Statistics.
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Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
Herbert Hurwitz,Louis Fehrenbacher,William Novotny,Thomas Cartwright,John D. Hainsworth,W. Heim,Jordan Berlin,Ari David Baron,Susan Griffing,Eric Holmgren,Napoleone Ferrara,Gwen Fyfe,Beth Rogers,Robert W. Ross,Fairooz F. Kabbinavar +14 more
TL;DR: The addition of bevacizumab to fluorouracil-based combination chemotherapy results in statistically significant and clinically meaningful improvement in survival among patients with metastatic colorectal cancer.
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Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.