N
Nicolas Ferry
Researcher at French Institute of Health and Medical Research
Publications - 75
Citations - 2244
Nicolas Ferry is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Transgene & Genetic enhancement. The author has an hindex of 26, co-authored 75 publications receiving 2176 citations. Previous affiliations of Nicolas Ferry include École Normale Supérieure & Pasteur Institute.
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Binding of yohimbine stereoisomers to α‐adrenoceptors in rat liver and human platelets
TL;DR: It is concluded that the aromatic A ring, the Nb atom, and the carboxymethyl moiety are important for the binding of yohimbine to the α‐adrenoceptor, the car boxymethyl group being important forThe α1/α2 specificity of the molecule.
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Mature hepatocytes actively divide and express gamma-glutamyl transpeptidase after D-galactosamine liver injury.
Olivier Kitten,Nicolas Ferry +1 more
TL;DR: It is demonstrated that hepatocytes can divide to restore the liver mass after D-galactosamine liver injury and that gamma-glutamyl transpeptidase can be re-expressed by mature hepatocytes during the recovery process.
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Specific Micro RNA-Regulated TetR-KRAB Transcriptional Control of Transgene Expression in Viral Vector-Transduced Cells
Virginie Pichard,Dominique Aubert,Sébastien Boni,Séverine Battaglia,Dejana Ivacik,Tuan Huy Nguyen,Patrick Arbuthnot,Nicolas Ferry +7 more
TL;DR: This work has developed expression systems that use combinations of a tetR-KRAB artificial transgene-repressor, endogenous miRNA silencing machinery and tissue specific promoters that provide a robust and easily adaptable method for achieving regulated transGene expression in different tissue types.
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In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV
Paula S. Montenegro-Miranda,Virginie Pichard,Dominique Aubert,L Ten Bloemendaal,Suzanne Duijst,D R de Waart,Nicolas Ferry,Piter J. Bosma +7 more
TL;DR: Adenoviral and Adenovirus-associated viral vectors are used for in vivo gene therapy of inherited liver disorders, such as Crigler–Najjar syndrome type 1 and the efficiency of clinically applicable doses of both vectors in the Gunn rat was compared.
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Long term transgene expression by hepatocytes transduced with retroviral vectors requires induction of immune tolerance to the transgene.
Juliana Puppi,Carole Guillonneau,Virginie Pichard,Marta Bellodi-Privato,Maria-Cristina Cuturi,Ignacio Anegon,Nicolas Ferry +6 more
TL;DR: In this article, the authors investigated whether immune response could be prevented by treatment with compounds known to induce tolerance in organ transplantation: CTLA4Ig and LF-15-0195.