Showing papers by "Nicolás Olea published in 2019"
TL;DR: BPA or BPS but not BPF was present in nearly all thermal paper receipts and BPA but not BPS concentrations were positively correlated with both estrogenic and anti‐androgenic activities.
58 citations
TL;DR: Data suggest that in utero exposure to Cd, Hg, and Cr could adversely affect fetal growth, whereas Mn and Cr appear to have a positive effect on gestational age.
51 citations
TL;DR: BPA appears to contribute to the hormone-like activity observed in sock extracts, and dermal exposure doses to BPA and parabens was higher from socks for children aged 36-48 months than from socks marketed for infants and children.
47 citations
TL;DR: An overview of effect biomarkers for reproductive toxicity that are substantiated by mechanistic information is presented, showing the activation of several receptors, such as PPARα, PPARγ, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure.
38 citations
TL;DR: According to these findings, neonates might be exposed to multiple sources of BPA and PBs in NICUs via inhalation, dermal, oral, and IV/parenteral routes and there is a need to address the future health implications for these extremely vulnerable patients.
Abstract: Background: Newborns in neonatal intensive care units (NICUs) are in contact with a variety of medical products whose production might include synthetic chemicals with hormonal activity. Objectives...
29 citations
TL;DR: The findings underline the potential relevance of adipose tissue as a biological matrix for exposure characterization to Cd, as well as for the assessment of long-term clinical implications of the exposure, particularly in obesity-related diseases.
20 citations
TL;DR: The findings do not support an association between urinary BPA concentrations and cognitive function or IQ among boys, except for working memory, suggesting that BPA may predominantly affect the behavior of children rather than their cognitive function, in line with previous epidemiologic studies.
Abstract: Background Bisphenol A (BPA) has been associated with impairments in children’s behavior, but few studies have investigated its relationship with cognitive function. Objective To investigate the association of urinary BPA concentrations with cognitive domains and intelligence quotient (IQ) in Spanish boys. Methods BPA levels were quantified by liquid chromatography-tandem mass spectrometry (LC–MS-MS) in one spot urine sample from 269 boys of the INMA-Granada cohort, in their follow-up at 9–11 years of age. Cognitive function was evaluated by a trained psychologist using a comprehensive neuropsychological test battery (including general intelligence, language skills, working memory, attention, impulsivity, visual-motor coordination, processing speed and executive function, among others). Cross-sectional associations between BPA levels and neuropsychological standardized scores were analyzed by adjusted linear and logistic regression models. Results Median (P25, P75) BPA concentrations were 4.76 (2.77, 9.03) μg/L and 4.75 (2.75, 10.2) μg/g of creatinine (Cr). Boys in the third and fourth quartile of volume-based BPA concentrations showed better processing speed scores than boys in the first quartile (β = 5.47; 95%CI: 1.4, 9.4 and β = 3.57; 95%CI: -0.4, 7.5, respectively); and boys in the third quartile showed better inhibitory control (β = 1.6; 95%CI: -0.3, 3.5) and impulsivity (β= -4.2; 95%CI: -9.0, 0.0). In contrast, boys in the fourth quartile showed poorer working memory scores than those in the first quartile (β= -1.0; 95%CI: -2.1, -0.1). All these associations were attenuated when Cr-standardized BPA concentrations were considered. Cr-based BPA concentrations were also associated with a higher risk of being below the 20th percentile of working memory scores [ORa = 1.51; 95%CI: 1.01, 2.25]. Discussion Our findings do not support an association between urinary BPA concentrations and cognitive function or IQ among boys, except for working memory. BPA was previously found to be associated with behavior problems in the same study population, suggesting that BPA may predominantly affect the behavior of children rather than their cognitive function, in line with previous epidemiologic studies.
15 citations
TL;DR: The results suggest that adipose tissue is potentially important matrix for the assessment of oxidative stress, which can be affected by specific environmental factors and might be relevant for public health.
4 citations