N
Nicole M. Martinez
Researcher at Yale University
Publications - 19
Citations - 1593
Nicole M. Martinez is an academic researcher from Yale University. The author has contributed to research in topics: Alternative splicing & RNA splicing. The author has an hindex of 11, co-authored 17 publications receiving 1181 citations. Previous affiliations of Nicole M. Martinez include University of Pennsylvania & Broad Institute.
Papers
More filters
Journal ArticleDOI
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
Elena Sotillo,David M. Barrett,Kathryn L. Black,Asen Bagashev,Derek A. Oldridge,Glendon S. Wu,Robyn T. Sussman,Claudia Lanauze,Marco Ruella,Matthew R. Gazzara,Nicole M. Martinez,Colleen T. Harrington,Elaine Y. Chung,Jessica Perazzelli,Ted J. Hofmann,Shannon L. Maude,Pichai Raman,Alejandro Barrera,Saar Gill,Simon F. Lacey,J. Joseph Melenhorst,David Allman,Elad Jacoby,Terry J. Fry,Crystal L. Mackall,Yoseph Barash,Kristen W. Lynch,John M. Maris,Stephan A. Grupp,Andrei Thomas-Tikhonenko +29 more
TL;DR: It is discovered that the underlying mechanism is the selection for preexisting alternatively spliced CD19 isoforms with the compromised CART-19 epitope, which suggests a possibility of targeting alternative CD19 ectodomains, which could improve survival of patients with B-cell neoplasms.
Journal ArticleDOI
Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn.
TL;DR: The proteins, pathways, and mechanisms that have been shown to regulate alternative splicing in human T cells are described and what is and is not known about the genes regulated by such factors are discussed.
Journal ArticleDOI
Alternative splicing networks regulated by signaling in human T cells.
Nicole M. Martinez,Qun Pan,Brian S. Cole,Christopher A. Yarosh,Grace A. Babcock,Florian Heyd,William Zhu,Sandya Ajith,Benjamin J. Blencowe,Kristen W. Lynch +9 more
TL;DR: This work uses RNA-seq profiling to identify 178 exons in 168 genes that exhibit robust changes in inclusion in response to stimulation of a human T-cell line, and finds that each regulatory network is specifically associated with distinct sequence features, suggesting that they are controlled by independent regulatory mechanisms.
Journal ArticleDOI
mRNA structure determines modification by pseudouridine synthase 1.
Thomas M. Carlile,Nicole M. Martinez,Cassandra Schaening,Amanda Su,Amanda Su,Tristan A Bell,Boris Zinshteyn,Boris Zinshteyn,Wendy V. Gilbert +8 more
TL;DR: A structure-dependent mode of mRNA target recognition by a conserved pseudouridine synthase is demonstrated and modulation of RNA structure is implicate as the probable mechanism to regulate mRNA pseudouridylation.
Journal ArticleDOI
Regulation and Function of RNA Pseudouridylation in Human Cells.
TL;DR: How much remains to be learned about the RNA targets of human pseudouridine synthases, their basis for recognizing distinct RNA sequences, and the mechanisms responsible for regulated RNA pseudouridylation is emphasized.