Nicoletta Pasquariello

TL;DR: It is demonstrated that axonal damage induces CB2R expression in central neurons and that stimulation of this receptor has a neuroprotective effect that is achieved through PI3K/Akt signaling.

TL;DR: It is demonstrated that murine 3T3-L1 fibroblasts have the machinery to bind, synthesize and degrade AEA, and that their differentiation into adipocytes increases by approximately twofold the binding efficiency of cannabinoid receptors (CBR), and by approximately threefold the catalytic efficiency of the AEA transporter and AEA hydrolase.

TL;DR: The elements that constitute the endocannabinod system (ECS) are described in order to put in a better perspective the role of this system in the control of human fertility, both in females and males.

TL;DR: These findings suggest that the trafficking of anandamide from the plasma membrane to the internal compartments of a cell occur via a nonvesicular mechanism mediated by cytosolic carriers.

TL;DR: This study provides unprecedented evidence that human spermatozoa exhibit a completely functional endocannabinoid system related to AEA and that the AEA-binding TRPV1 receptor could be involved in the sperm fertilizing ability.