N
Nidhi Sofat
Researcher at St George's, University of London
Publications - 73
Citations - 1956
Nidhi Sofat is an academic researcher from St George's, University of London. The author has contributed to research in topics: Osteoarthritis & Rheumatoid arthritis. The author has an hindex of 18, co-authored 61 publications receiving 1613 citations. Previous affiliations of Nidhi Sofat include University of London & St George’s University Hospitals NHS Foundation Trust.
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Journal ArticleDOI
Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
Kim S. Midwood,Sandra Sacre,Anna M. Piccinini,Julia J. Inglis,Annette Trebaul,Annette Trebaul,Emma Chan,Emma Chan,Stefan K. Drexler,Stefan K. Drexler,Nidhi Sofat,Masahide Kashiwagi,Gertraud Orend,Fionula M. Brennan,Brian M. J. Foxwell +14 more
TL;DR: Tenascin-C is identified as a novel endogenous activator of TLR4-mediated immunity that mediates persistent synovial inflammation and tissue destruction in arthritic joint disease.
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What makes osteoarthritis painful? The evidence for local and central pain processing
TL;DR: Data demonstrate that pain perception in OA is complex in being influenced by local factors and activation of central pain-processing pathways, and possible directions for the future management of pain in this condition are suggested based on recent clinical studies.
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Hand to Mouth: A Systematic Review and Meta-Analysis of the Association between Rheumatoid Arthritis and Periodontitis.
TL;DR: A significant association between RA and periodontitis is supported by the results of the systematic review and meta-analysis of studies comparing RA to healthy controls and this is not replicated when comparingRA to OA controls.
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Analysing the role of endogenous matrix molecules in the development of osteoarthritis
TL;DR: The contribution of endogenous ECM molecules to joint destruction will be discussed and a deeper understanding of the pathways stimulated by endogenous ligands could offer potential avenues for novel therapies in the future.
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Microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover, neurogenesis and inflammation
Anasuya Kuttapitiya,L. Assi,Ken Laing,Caroline B. Hing,Philip Mitchell,Guy Whitley,A. Harrison,Franklyn A. Howe,Vivian Ejindu,Christine Heron,Nidhi Sofat +10 more
TL;DR: This study is the first to employ detailed histological analysis and microarray techniques to investigate knee OA BMLs and demonstrated areas of high metabolic activity expressing pain sensitisation, neuronal, extracellular matrix and proinflammatory signalling genes that may explain their strong association with pain.