N
Niels Hellings
Researcher at University of Hasselt
Publications - 135
Citations - 5296
Niels Hellings is an academic researcher from University of Hasselt. The author has contributed to research in topics: Multiple sclerosis & Experimental autoimmune encephalomyelitis. The author has an hindex of 37, co-authored 117 publications receiving 4345 citations. Previous affiliations of Niels Hellings include Transnational University Limburg.
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Journal ArticleDOI
Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level.
Koen Venken,Niels Hellings,Marielle Thewissen,Veerle Somers,Karen Hensen,Jean-Luc Rummens,Robert Medaer,Raymond Hupperts,Piet Stinissen +8 more
TL;DR: Analysis of forkhead box P3 at the single‐cell level in MS patients and controls suggests that Tregs accumulate in the CSF of RR‐MS patients, in an attempt to down‐regulate local inflammation in the central nervous system.
Journal ArticleDOI
Systemic immune activation leads to neuroinflammation and sickness behavior in mice.
Steven Biesmans,Theo Meert,Jan A. Bouwknecht,Paul D. Acton,Nima Davoodi,Patrick De Haes,Jacobine Kuijlaars,Xavier Langlois,Liam J. R. Matthews,Luc Ver Donck,Niels Hellings,Rony Nuydens +11 more
TL;DR: It is reported that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice.
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Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression.
TL;DR: Analysis of IFN-β and glatiramer acetate-treated MS patients showed that these immunomodulatory drugs modify nTreg homeostasis, indicating that inflammatory processes drive the homeostatic turnover of mTregs during the early disease stage.
Journal ArticleDOI
Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression
Koen Venken,Niels Hellings,Karen Hensen,Jean-Luc Rummens,Robert Medaer,Marie B. D'hooghe,Bénédicte Dubois,Jef Raus,Piet Stinissen +8 more
TL;DR: In this article, the phenotypic and functional characteristics of CD4(+)CD25(+) T cells isolated from the peripheral blood of patients with relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis (SP-MS) were investigated.
Journal Article
Secondary progressive in contrast to relapsing: remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T cell function and FOXP3 expression
Koen Venken,Niels Hellings,Karen Hensen,Jean-Luc Rummens,Robert Medaer,Marie B. D'hooghe,Bénédicte Dubois,Jef Raus,Piet Stinissen +8 more
TL;DR: These data are the first to demonstrate differences in function and FOXP3 expression of CD4+CD25+ T cells from patients with RR‐ and SP‐MS, indicating that Treg function is more affected in the early phase of the disease process.