N
Niels Tvede
Researcher at Copenhagen University Hospital
Publications - 17
Citations - 1214
Niels Tvede is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Peripheral blood mononuclear cell & Interleukin 2. The author has an hindex of 10, co-authored 17 publications receiving 1126 citations.
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Journal ArticleDOI
Targeting interleukin‐15 in patients with rheumatoid arthritis: A proof‐of‐concept study
Bo Baslund,Niels Tvede,Bente Danneskiold-Samsøe,Per Larsson,Gabriel S. Panayi,Joergen Petersen,Lars Jelstrup Petersen,Frank J. Beurskens,Janine Schuurman,Jan G. J. van de Winkel,Paul W. H. I. Parren,J. Alastair Gracie,Sarah L. Jongbloed,Foo Y. Liew,Iain B. McInnes +14 more
TL;DR: Clinical data suggest for the first time that IL-15 could represent a novel therapeutic target in RA and HuMax-IL15 was well tolerated clinically, with no significant effects on T lymphocyte subset and natural killer cell numbers.
Journal Article
Malignancies in Wegener's granulomatosis: incidence and relation to cyclophosphamide therapy in a cohort of 293 patients.
Mikkel Faurschou,Inge Juul Sørensen,Lene Mellemkjær,Anne Gitte Loft,Bjarne Svalgaard Thomsen,Niels Tvede,Bo Baslund +6 more
TL;DR: Treatment with high cumulative CYC doses implies a substantial risk of late-occurring, serious malignancies in Wegener's granulomatosis, and the need for development of new treatment regimens in WG is emphasized.
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A prospective study of vasculitis patients collected in a five year period: evaluation of the Chapel Hill nomenclature
TL;DR: The Chapel Hill nomenclature, supplemented with surrogate parameters, failed to act as diagnostic criteria in Wegener's granulomatosis and microscopic polyangiitis.
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ASDAS, BASDAI and different treatment responses and their relation to biomarkers of inflammation, cartilage and bone turnover in patients with axial spondyloarthritis treated with TNFα inhibitors
Susanne Juhl Pedersen,Inge Juul Sørensen,Patrick Garnero,Julia S. Johansen,Ole Rintek Madsen,Niels Tvede,Michael Sejer Hansen,Gorm Thamsborg,Lis Smedegaard Andersen,O Majgaard,Anne Gitte Loft,Jon Erlendsson,Karsten Asmussen,Anne Grethe Jurik,J. Møller,Maria Hasselquist,Dorrit Mikkelsen,T Skjødt,Robert G. W. Lambert,Annette Hansen,Mikkel Østergaard +20 more
TL;DR: Very high ASDAS were associated with high levels of inflammatory biomarkers, while high BASDAI were not related to any biomarkers and mixed modeling demonstrated significant longitudinal associations between ASDAS and IL-6, VEGF, MMP-3 and osteocalcin.
Journal ArticleDOI
Responsiveness of the Ankylosing Spondylitis Disease Activity Score (ASDAS) and clinical and MRI measures of disease activity in a 1-year follow-up study of patients with axial spondyloarthritis treated with tumour necrosis factor alpha inhibitors.
Susanne Juhl Pedersen,Inge Juul Sørensen,Kay-Geert A. Hermann,Ole Rintek Madsen,Niels Tvede,Michael Sejer Hansen,Gorm Thamsborg,Lis Smedegaard Andersen,O Majgaard,Anne Gitte Loft,Jon Erlendsson,Karsten Asmussen,Julia S. Johansen,Anne Grethe Jurik,Jakob M Møller,Maria Hasselquist,Dorrit Mikkelsen,T Skjødt,Annette Hansen,Mikkel Østergaard +19 more
TL;DR: AS demonstrates construct validity and high responsiveness during treatment with TNFα inhibitors in patients with SpA, and the proposed thresholds for disease activity and treatment response need further validation.