N
Niels Willi
Researcher at University of Basel
Publications - 32
Citations - 5281
Niels Willi is an academic researcher from University of Basel. The author has contributed to research in topics: Prostate cancer & Tissue microarray. The author has an hindex of 19, co-authored 30 publications receiving 4585 citations.
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Journal ArticleDOI
Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients.
Lukas Bubendorf,Alain Schöpfer,Urs Wagner,Guido Sauter,Holger Moch,Niels Willi,Thomas C. Gasser,Michael J. Mihatsch +7 more
TL;DR: It is shown that bone, lung, and liver are the most frequent sites of distant prostate cancer metastases and there are strong arguments for the existence and clinical significance of a backward venous spread to the spine, which is likely to occur early in the metastatic process.
Journal ArticleDOI
Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction.
Thomas Menter,Jasmin D. Haslbauer,Ronny Nienhold,Spasenija Savic,Helmut Hopfer,Nikolaus Deigendesch,Stephan Frank,Daniel Turek,Niels Willi,Hans Pargger,Stefano Bassetti,Joerg D. Leuppi,Gieri Cathomas,Markus Tolnay,Kirsten D. Mertz,Alexandar Tzankov +15 more
TL;DR: The general extent of organ involvement and the microscopic changes in the lungs remain insufficiently characterised, and autopsies are essential to elucidate COVID‐19‐associated organ alterations.
Journal Article
Survey of Gene Amplifications during Prostate Cancer Progression by High-Throughput Fluorescence in Situ Hybridization on Tissue Microarrays
Lukas Bubendorf,Juha Kononen,Pasi A. Koivisto,Peter Schraml,Holger Moch,Thomas C. Gasser,Niels Willi,Michael J. Mihatsch,Guido Sauter,Olli-P. Kallioniemi +9 more
TL;DR: FISH to tissue microarray sections enables high-throughput analysis of genetic alterations contributing to cancer development and progression and implicate a role for amplification of androgen receptor in hormonal therapy failure and that of MYC in the metastatic progression of human prostate cancer.
Journal Article
Loss of NKX3.1 Expression in Human Prostate Cancers Correlates with Tumor Progression1,2
Cai Bowen,Lukas Bubendorf,H. James Voeller,Rebecca Slack,Niels Willi,Guido Sauter,Thomas C. Gasser,Pasi A. Koivisto,Ernest E. Lack,Juha Kononen,Olli-P. Kallioniemi,Edward P. Gelmann +11 more
TL;DR: The data show that NKX3.1 expression is highly, but not exclusively, specific for the prostate, and is strongly associated with hormone-refractory disease and advanced tumor stage in prostate cancer.
Journal ArticleDOI
Hormone Therapy Failure in Human Prostate Cancer: Analysis by Complementary DNA and Tissue Microarrays
Lukas Bubendorf,Meelis Kolmer,Meelis Kolmer,Juha Kononen,Pasi A. Koivisto,Spyro Mousses,Yi Chen,Eija Mahlamäki,Peter Schraml,Holger Moch,Niels Willi,Abdel G. Elkahloun,Thomas G. Pretlow,Thomas C. Gasser,Michael J. Mihatsch,Guido Sauter,Olli Kallioniemi +16 more
TL;DR: The combination of cDNA and tissue microarray technologies enables rapid identification of genes associated with progression of prostate cancer to the hormone-refractory state and may facilitate analysis of the role of the encoded gene products in the pathogenesis of human prostate cancer.