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Nigel J. Savery
Researcher at University of Bristol
Publications - 75
Citations - 2688
Nigel J. Savery is an academic researcher from University of Bristol. The author has contributed to research in topics: RNA polymerase & Transcription (biology). The author has an hindex of 28, co-authored 69 publications receiving 2342 citations. Previous affiliations of Nigel J. Savery include University of Birmingham & University of Massachusetts Amherst.
Papers
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Journal ArticleDOI
Structural Basis for Bacterial Transcription-Coupled DNA Repair
Alexandra M. Deaconescu,Anna L Chambers,Anna L Chambers,Abigail J Smith,Bryce E. Nickels,Ann Hochschild,Nigel J. Savery,Seth A. Darst +7 more
TL;DR: Comparison with the translocation module of RecG as well as other structural features indicate that TRCF function involves large-scale conformational changes, which provide mechanistic insights into T RCF function.
Journal ArticleDOI
A comparative analysis of synthetic genetic oscillators.
TL;DR: The state of the art in the design and construction of oscillators is reviewed, comparing the features of each of the main networks published to date, the models used for in silico design and validation and, where available, relevant experimental data.
Journal ArticleDOI
Transcription activation at Class II CRP-dependent promoters: identification of determinants in the C-terminal domain of the RNA polymerase α subunit
Nigel J. Savery,Georgina S. Lloyd,Mark Kainz,Tamas Gaal,Wilma Ross,Richard H. Ebright,Richard L. Gourse,Stephen J. W. Busby +7 more
TL;DR: It is proposed that, in the ternary complex of RNA polymerase, CRP and a Class II CRP‐dependent promoter, this determinant in αCTD interacts directly with CRP, and is distinct from and on the opposite face to the proposed determinant forαCTD–CRP interaction in Class I CRP-dependent transcription.
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BSim: An Agent-Based Tool for Modeling Bacterial Populations in Systems and Synthetic Biology
Thomas E. Gorochowski,Antoni Matyjaszkiewicz,Thomas Todd,Neeraj Oak,Kira Kowalska,Stephen Reid,Krasimira Tsaneva-Atanasova,Nigel J. Savery,Claire S. Grierson,Mario di Bernardo +9 more
TL;DR: BSim, a highly flexible agent-based computational tool for analyzing the relationships between single-cell dynamics and population level features, is introduced, enabling the modeling of bacterial behavior in more realistic three-dimensional, complex environments.
Journal ArticleDOI
Transcription activation at Class II CRP-dependent promoters: the role of different activating regions
TL;DR: Abortive initiation assays have been used to quantify the effects of positive control substitutions in each activating region on the kinetics of transcription initiation at the Class II CRP- dependent promoter pmelRcon.