Nikhil Sharma

TL;DR: Sensory stimuli, by inducing NPAS4 and its target genes, differentially control spatial features of neuronal inhibition in a way that restricts the output of the neuron while creating a dendritic environment that is permissive for plasticity.

TL;DR: It is shown that somatosensory neurogenesis gives rise to neurons in a transcriptionally unspecialized state, characterized by co-expression of transcription factors that become restricted to select subtypes as development proceeds, and this support a model in which cues that emanate from intermediate and final target fields promote neuronal diversification in part by transitioning cells from a transcriptally un specialized state to transcriptionally distinct subtypes by modulating the selection of subtype-restricted transcription factors.

TL;DR: In this paper, the authors investigate how recommendations affect information choices, and 93 participants browsed online news that featured explicit (average rating) or implicit (times viewed) recommendations or no recommendations (control group) while news exposure was logged.

TL;DR: It is suggested that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects.

TL;DR: Deletion analysis of EBNA3C identified a motif within amino acids 140-149 important for both the binding and regulation of Rb, which suggests that other human malignancies might use a similar strategy to regulate the Rb protein.