N
Nikolaos Tezapsidis
Researcher at University of California, San Diego
Publications - 31
Citations - 1789
Nikolaos Tezapsidis is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Leptin & Presenilin. The author has an hindex of 20, co-authored 31 publications receiving 1690 citations. Previous affiliations of Nikolaos Tezapsidis include Uniformed Services University of the Health Sciences & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Obesity-related leptin regulates Alzheimer’s Aβ
Darius C Fewlass,Karina Noboa,F. Xavier Pi-Sunyer,Jane M. Johnston,Shi D Yan,Nikolaos Tezapsidis +5 more
TL;DR: Leptin's ability to modify Aβ levels in vitro and in vivo is demonstrated and it is shown that leptin can modulate bidirectional Aβ kinesis, reducing its levels extracellularly.
Journal ArticleDOI
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.
Steven J. Greco,Kathryn J. Bryan,Sraboni Sarkar,Xiongwei Zhu,Mark A. Smith,J. Wesson Ashford,Jane M. Johnston,Nikolaos Tezapsidis,Gemma Casadesus +8 more
TL;DR: The efficacy of leptin in ameliorating the Alzheimer's disease (AD)-like pathology in 6-month old CRND8 transgenic mice (TgCRND8) following 8 weeks of treatment is examined, solidly demonstrating the potential for leptin as a disease modifying therapeutic in transgenic animals of AD, driving optimism for its safety and efficacy in humans.
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Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
TL;DR: The data implicate that AMPK is a key regulator of both AD-related pathways, and direct stimulation of AMPK with the cell-permeable activator, 5-aminoimidazole-4-carboxyamide ribonucleoside, replicated leptin's effects and conversely, Compound C, an inhibitor of AM PK, blocked leptin's action.
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Leptin reduces Alzheimer’s disease-related tau phosphorylation in neuronal cells
Steven J. Greco,Sraboni Sarkar,Jane M. Johnston,Xiongwei Zhu,Bo Su,Gemma Casadesus,J. Wesson Ashford,Mark A. Smith,Nikolaos Tezapsidis +8 more
TL;DR: Leptin, which ameliorates both amyloid beta and tau-related pathological pathways, holds promise as a novel therapeutic for Alzheimer's disease.
Journal ArticleDOI
Leptin: a novel therapeutic strategy for Alzheimer's disease.
Nikolaos Tezapsidis,Jane M. Johnston,Mark A. Smith,J. Wesson Ashford,Gemma Casadesus,Nikolaos K. Robakis,Benjamin Wolozin,George Perry,George Perry,Xiongwei Zhu,Steven J. Greco,Sraboni Sarkar +11 more
TL;DR: Adipocyte-derived leptin appears to regulate a number of features defining Alzheimer's disease at the molecular and physiological level and chronic administration of leptin resulted in a significant improvement in the cognitive performance of transgenic animal models.