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Showing papers by "Nikolaus J. Sucher published in 1997"


Journal ArticleDOI
01 May 1997-Neuron
TL;DR: Nitric oxide is a signaling molecule that has capin the immune system in work by DeGroote and Fang and the activation of bacterial resistance is achieved by by observations in the cardiovascular and immune sysS-nitrosylation of proteins involved in defense

696 citations


Journal ArticleDOI
TL;DR: In vitro and in vivo studies suggest that the use of selective NMDA receptor antagonists or Ca2+ channel blockers should be useful in preventing or at least abating neuronal loss in the retina.

365 citations


01 Jan 1997
TL;DR: The activation of bacterial resistance is achieved by by observations in the cardiovascular and immune sys- S-nitrosylation of proteins involved in defense, and the killing of tumor cells and bacteria by the the signal and the regulator of the response.
Abstract: Nitric oxide (NO) is a signaling molecule that has cap- in the immune system in work by DeGroote and Fang tured our imagination. According to the common view, (DeGroote et al., 1996). These researchers found that NO diffuses over a large sphere of influence, moving bacterial virulence is conferred by a gene that protects freely through membranes of target cells to raise levels against the lethal effects of SNOs produced by the (muof cGMP. In the brain, NO influences synaptic plasticity, rine) host, whereas NO is harmless against the same apoptosis, neuronal development, and even complex bacteria. Molecular recognition of the SNO onslaught behavioral responses. This image has been reinforced and the activation of bacterial resistance is achieved by by observations in the cardiovascular and immune sys- S-nitrosylation of proteins involved in defense (Hauslatems, for example, the relaxation of blood vessels by den et al., 1996). Thus, in this system, S-nitrosylation is cGMP, and the killing of tumor cells and bacteria by the the signal and the regulator of the response. macrophage NO synthase (NOS).

24 citations