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Nilesh M. Agalave
Researcher at University of Texas at Dallas
Publications - 22
Citations - 577
Nilesh M. Agalave is an academic researcher from University of Texas at Dallas. The author has contributed to research in topics: Arthritis & Microglia. The author has an hindex of 8, co-authored 20 publications receiving 407 citations. Previous affiliations of Nilesh M. Agalave include Karolinska Institutet.
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Journal ArticleDOI
Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis
Nilesh M. Agalave,Max Larsson,Sally Abdelmoaty,Jie Su,Azar Baharpoor,Peter Lundbäck,Karin Palmblad,Ulf Andersson,Helena Erlandsson Harris,Camilla I. Svensson +9 more
TL;DR: It is demonstrated that spinal HMGB1 contributes to nociceptive signal transmission via activation of TLR4 and point to disulfideHMGB1 inhibition as a potential therapeutic strategy in treatment of chronic inflammatory pain.
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Collagen antibody-induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency.
Duygu B. Bas,Jie Su,Katalin Sandor,Nilesh M. Agalave,Johanna Lundberg,Simone Codeluppi,Azar Baharpoor,Kutty Selva Nandakumar,Rikard Holmdahl,Camilla I. Svensson +9 more
TL;DR: The findings of a time-dependent prostaglandin and spinal glial contribution to antibody-induced pain highlight the importance of using appropriate disease models to assess joint-related pain.
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Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain
TL;DR: An overview ofHMGB1 as a proinflammatory mediator is given, focusing particularly on the role of HMGB1 in the induction and maintenance of hypersensitivity in experimental models of pain and the therapeutic potential of targeting HMGB 1 in conditions of chronic pain is discussed.
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Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis.
Teresa Fernandez-Zafra,Tianle Gao,Alexandra Jurczak,Katalin Sandor,Zoe Hore,Nilesh M. Agalave,Jie Su,Johanna Estelius,Jon Lampa,Tomas Hökfelt,Zsuzsanna Wiesenfeld-Hallin,Xiao-Jun Xu,Franziska Denk,Camilla I. Svensson +13 more
TL;DR: There are subtle sex differences in microglial expression profiles independent of arthritis, and experiments failed to identify the underlying mRNA correlates of microglia actions in the late phase of the CAIA model.
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Pattern recognition receptors in chronic pain: Mechanisms and therapeutic implications.
TL;DR: The current knowledge regarding the role of PRRs in chronic pain is reviewed and the promise and challenges of targeting PRRs as a novel therapeutic approach for chronic pain are discussed.