K
Karin Palmblad
Researcher at Karolinska University Hospital
Publications - 45
Citations - 4909
Karin Palmblad is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Arthritis & HMGB1. The author has an hindex of 13, co-authored 44 publications receiving 4571 citations. Previous affiliations of Karin Palmblad include Karolinska Institutet & Boston Children's Hospital.
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Journal ArticleDOI
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes.
Ulf Andersson,Haichao Wang,Karin Palmblad,Ann-Charlotte Aveberger,Ona Bloom,Helena Erlandsson-Harris,Alfred Janson,R. Kokkola,Minghuang Zhang,Huan Yang,Kevin J. Tracey +10 more
TL;DR: Results indicate that, like other cytokine mediators of endotoxin lethality (e.g., TNF and IL-1), extracellular HMG-1 is a regulator of monocyte proinflammatory cytokine synthesis.
Journal ArticleDOI
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
Huan Yang,Hulda Sigridur Hreggvidsdottir,Karin Palmblad,Haichao Wang,Mahendar Ochani,Jianhua Li,Ben Lu,Sangeeta S. Chavan,Mauricio Rosas-Ballina,Yousef Al-Abed,Shizuo Akira,Angelika Bierhaus,Helena Erlandsson-Harris,Ulf Andersson,Kevin J. Tracey +14 more
TL;DR: It is shown that Toll-like receptor 4 (TLR4), a pivotal receptor for activation of innate immunity and cytokine release, is required for HMGB1-dependent activation of macrophage TNF release.
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Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity
R. Kokkola,Jian Li,Erik Sundberg,Ann-Charlotte Aveberger,Karin Palmblad,Huan Yang,Kevin J. Tracey,Ulf Andersson,H. Erlandsson Harris +8 more
TL;DR: Systemic administration of anti-HMGB-1 antibodies or A-box protein significantly reduced the mean arthritis score, the disease-induced weight loss, and the histologic severity of arthritis.
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The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation.
Hulda Sigridur Hreggvidsdottir,Therese Östberg,Heidi Wähämaa,Hanna Schierbeck,Ann-Charlotte Aveberger,Lena Klevenvall,Karin Palmblad,Lars Ottosson,Ulf Andersson,Helena Erlandsson Harris +9 more
TL;DR: HMGB1 acts broadly with many but not all immunostimulatory molecules to amplify their activity in a synergistic manner and cannot induce detectable IL‐6 production on its own.
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High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis
R. Kokkola,Erik Sundberg,A.-K. Ulfgren,Karin Palmblad,Jian Li,Haichao Wang,Luis Ulloa,Huan Yang,X.-J. Yan,R. Furie,Nicholas Chiorazzi,Kevin J. Tracey,Ulf Andersson,H. Erlandsson Harris +13 more
TL;DR: The proinflammatory mediator HMGB-1 was abundantly expressed as a nuclear, cytoplasmic, and extracellular component in synovial tissues from RA patients and from rats with experimental arthritis, suggesting a pathogenetic role for HMGB -1 insynovitis and indicate a new potential therapeutic target molecule.