Nirav Daphtary

TL;DR: It is demonstrated that following airway exposure with an asthma-relevant allergen, activation of classical and alternative NF-κB pathways occurs within the airway epithelium and may coordinately contribute to allergic inflammation, AHR, and fibrotic airway remodeling.

TL;DR: It is indicated that HDM induces ER stress in airway epithelial cells and that ATF6α and ERp57 play a significant role in the development of cardinal features of allergic airways disease.

TL;DR: It is shown that SESI-MS breathprinting can be used to robustly classify acute P. aeruginosa and S. aureus mouse lung infections at any time during the 120 h infection/clearance process.

TL;DR: It is shown that ERp57 levels are increased in the airway epithelium of asthmatic patients and in mice with allergic airways disease, and is associated with redox modification of proinflammatory, apoptotic, and fibrotic mediators and contributes to airways hyperresponsiveness.

TL;DR: In this article, the authors examined alterations in glycolysis in sputum samples from asthmatic patients and primary human nasal cells and used murine models of allergic asthma, as well as primary mouse tracheal epithelial cells, to evaluate the relevance of gly co-lysis.