Nisim Perets

TL;DR: This method for noninvasive in vivo neuroimaging and tracking of exosomes, based on glucose-coated gold nanoparticle (GNP) labeling and computed tomography imaging, can serve as a powerful diagnostic tool for various brain disorders and could potentially enhance exosome-based treatments for neuronal recovery.

TL;DR: It is demonstrated that when given intranasally, exosomes derived from mesenchymal stem cells could pass the blood brain barrier, and migrate to the injured spinal cord area, and MSC-Exo loaded with phosphatase and tensin homolog small interfering RNA (ExoPTEN) could attenuate the expression of PTEN in thejured spinal cord region followingintranasal administrations.

TL;DR: It is found that MSC-exo specifically targeted and accumulated in pathologically relevant murine models brains regions up to 96 h post administration, while in healthy controls they showed a diffuse migration pattern and clearance by 24 h, suggesting that the homing mechanism is inflammatory-driven.

TL;DR: In this paper, the exosomes secreted from mesenchymal stem cells (MSC-exo) were used to treat autistic-like behaviors in BTBR mice.

TL;DR: It is demonstrated that a single transplantation of MSC or NurOwn have long‐lasting benefits, while NurOwn may be superior to MSC treatment.