N
Nithya Balakrishnan
Researcher at National Institute of Technology, Tiruchirappalli
Publications - 10
Citations - 208
Nithya Balakrishnan is an academic researcher from National Institute of Technology, Tiruchirappalli. The author has contributed to research in topics: Chemistry & Ligand (biochemistry). The author has an hindex of 4, co-authored 6 publications receiving 66 citations.
Papers
More filters
Journal ArticleDOI
Synthesis and Anticancer Activity of [RuCl2(η6-arene)(aroylthiourea)] Complexes-High Activity against the Human Neuroblastoma (IMR-32) Cancer Cell Line.
Srividya Swaminathan,Jebiti Haribabu,Naveen Kumar Kalagatur,Ramaiah Konakanchi,Nithya Balakrishnan,Nattamai Bhuvanesh,Ramasamy Karvembu +6 more
TL;DR: The study concluded that the complexes promoted the oxidative stress-mediated apoptotic death of the cancer cells through the generation of intracellular ROS, depletion of MMP, and damage of the nuclear material.
Journal ArticleDOI
Impact of aliphatic acyl and aromatic thioamide substituents on the anticancer activity of Ru(II)-p-cymene complexes with acylthiourea ligands—in vitro and in vivo studies
Srividya Swaminathan,Jebiti Haribabu,Jebiti Haribabu,Mohamed Kasim Mohamed Subarkhan,Dasararaju Gayathri,Nithya Balakrishnan,Nattamai Bhuvanesh,Cesar Echeverria,Ramasamy Karvembu +8 more
TL;DR: In this paper, six different acylthiourea ligands (L1-L6) and their corresponding Ru(II)-p-cymene complexes (P1-P6) were designed to explore the structure-activity relationship of the complexes upon aliphatic chain and aromatic conjugation on the C- and N-terminals, respectively.
Journal ArticleDOI
Thiosemicarbazone(s)-anchored water soluble mono- and bimetallic Cu(II) complexes: enzyme-like activities, biomolecular interactions, anticancer property and real-time live cytotoxicity
Nithya Balakrishnan,Jebiti Haribabu,Jebiti Haribabu,Ananda Krishnan Dhanabalan,Srividya Swaminathan,Sijia Sun,Dya Fita Dibwe,Nattamai Bhuvanesh,Suresh Awale,Ramasamy Karvembu +9 more
TL;DR: The catecholase-mimicking activity of complexes 1-5 was examined spectrophotometrically, and the results revealed that all the complexes except 5 had the ability to oxidize 3, 5-di-tert-butylcatechol (3,5-DTBC) to 3,5 -di- tert- butylquinone (3-5-DTBQ) under aerobic conditions with moderate turnover numbers.
Journal ArticleDOI
Zinc(II) complexes of indole thiosemicarbazones: DNA/protein binding, molecular docking and in vitro cytotoxicity studies
Nithya Balakrishnan,Jebiti Haribabu,Jebiti Haribabu,Dhanabalan Anantha Krishnan,Srividya Swaminathan,Dharmasivam Mahendiran,Nattamai Bhuvanesh,Ramasamy Karvembu +7 more
TL;DR: Four Zn(II) complexes (1–4) featuring indole thiosemicarbazones were synthesized and well-characterized by elemental analyses and various spectroscopic techniques, which implied that the complexes bound to CT DNA via intercalation, and complex 4 showed a higher binding affinity than the other complexes.
Journal ArticleDOI
Tunable anticancer activity of furoylthiourea‐based Ru(II)‐arene complexes and their mechanism of action
Srividya Swaminathan,Jebiti Haribabu,Naveen Kumar Kalagatur,Maroli Nikhil,Nithya Balakrishnan,Nattamai Bhuvanesh,Krishna Kadirvelu,Ponmalai Kolandaivel,Ramasamy Karvembu +8 more
TL;DR: In this paper, 14 RuII -arene (p-cymene/benzene) complexes (C1-C14) have been synthesized by varying the N-terminal substituent in the furoylthiourea ligand and satisfactorily characterized by using analytical and spectroscopic techniques.