Noboru Mesaki

TL;DR: These findings are novel and important in that they provide the first evidence showing that skeletal muscles are capable of locally synthesizing sex steroid hormones from circulating DHEA or testosterone in cultured muscle cells in a dose-dependent manner.

TL;DR: Evidence is provided that the elastic properties of central, but not peripheral, arteries fluctuate significantly with the phases of the menstrual cycle, as well as the variations in central and peripheral arterial elasticity, blood pressure, and carotid intima–media thickness.

TL;DR: Examination of sex differences in the levels of dehydroepiandrosterone (DHEA), free testosterone, DHT, and steroidogenesis-related enzymes in rat's skeletal muscle before and after a single bout of exercise suggests that acute exercise enhances the local bioactive androgen metabolism in the skeletal muscle of both sexes.

TL;DR: A single bout of exercise can influence the steroidogenic system in skeletal muscle, and these alterations differ between sexes, so the acute exercise-induced alteration of steroidogenic enzymes may enhance the local steroidogenesis in the skeletal muscle in both sexes.

TL;DR: Endurance exercise training enhances the muscular DHT concentration through 5α-reductase in the skeletal muscle of rats, suggesting that local bioactive androgen metabolism may participate in exercise training-induced skeletal muscular adaptation.