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Nobuhide Oshitani
Researcher at Osaka City University
Publications - 223
Citations - 4846
Nobuhide Oshitani is an academic researcher from Osaka City University. The author has contributed to research in topics: Ulcerative colitis & Inflammatory bowel disease. The author has an hindex of 37, co-authored 223 publications receiving 4564 citations.
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Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent
Toshio Watanabe,Kazuhide Higuchi,Atsushi Kobata,Hikaru Nishio,Tetsuya Tanigawa,Masatsugu Shiba,Kazunari Tominaga,Yasuhiro Fujiwara,Nobuhide Oshitani,Takashi Asahara,Koji Nomoto,Koji Takeuchi,Tetsuo Arakawa +12 more
TL;DR: Indomethacin may injure the small intestine through a TLR4/MyD88-dependent pathway through an activation of an inflammatory cascade via the accessory protein MyD88.
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Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study.
Toshio Watanabe,Satoshi Sugimori,Natsuhiko Kameda,Hirohisa Machida,Hirotoshi Okazaki,Tetsuya Tanigawa,Kenji Watanabe,Kazunari Tominaga,Yasuhiro Fujiwara,Nobuhide Oshitani,Kazuhide Higuchi,Tetsuo Arakawa +11 more
TL;DR: Low-dose enteric-coated aspirin frequently damages the small intestine, and misoprostol is effective in the treatment of aspirin-induced enteropathy.
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Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid.
Toshio Watanabe,Hikaru Nishio,Tetsuya Tanigawa,Hirokazu Yamagami,Hirotoshi Okazaki,Kenji Watanabe,Kazunari Tominaga,Yasuhiro Fujiwara,Nobuhide Oshitani,Takashi Asahara,Koji Nomoto,Kazuhide Higuchi,Koji Takeuchi,Tetsuo Arakawa +13 more
TL;DR: LcS exhibits a prophylactic effect on indomethacin-induced enteropathy by suppressing the LPS/TLR4 signaling pathway and that this probiotic effect of LcS may be mediated by L-lactic acid.
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Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats.
Fumio Tanaka,Kazunari Tominaga,Masahiro Ochi,Tetsuya Tanigawa,Toshio Watanabe,Yasuhiro Fujiwara,Kensuke Ohta,Nobuhide Oshitani,Kazuhide Higuchi,Tetsuo Arakawa +9 more
TL;DR: It is concluded that exogenous MSCs accumulated in inflamed tissues and ameliorated DSS-induced colitis via a local anti-inflammatory action.
Journal ArticleDOI
Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats.
Masahiro Ochi,Kazunari Tominaga,Fumio Tanaka,Tetsuya Tanigawa,Masatsugu Shiba,Toshio Watanabe,Yasuhiro Fujiwara,Nobuhide Oshitani,Kazuhide Higuchi,Tetsuo Arakawa +9 more
TL;DR: Delayed gastric emptying at acute phase of continuous stress was mediated through sympathetic pathway, while acceleration at chronic phase was mediated via increased active ghrelin release from the stomach.