K
Koji Nomoto
Researcher at Juntendo University
Publications - 127
Citations - 8714
Koji Nomoto is an academic researcher from Juntendo University. The author has contributed to research in topics: Lactobacillus casei & Lactobacillus. The author has an hindex of 47, co-authored 126 publications receiving 7306 citations. Previous affiliations of Koji Nomoto include Tokyo University of Agriculture.
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Journal ArticleDOI
Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson's Disease
Satoru Hasegawa,Sae Goto,Hirokazu Tsuji,Tatsuya Okuno,Takashi Asahara,Koji Nomoto,Akihide Shibata,Yoshiro Fujisawa,Tomomi Minato,Akira Okamoto,Kinji Ohno,Masaaki Hirayama +11 more
TL;DR: The permeability to LPS is likely to be increased without compromising the integrity of intestinal mucosa in PD, and the increased intestinal permeability in PD may make the patients susceptible to intestinal dysbiosis.
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Gut Dysbiosis and Detection of “Live Gut Bacteria” in Blood of Japanese Patients With Type 2 Diabetes
Junko Sato,Akio Kanazawa,Fuki Ikeda,Tomoaki Yoshihara,Hiromasa Goto,Hiroko Abe,Koji Komiya,Minako Kawaguchi,Tomoaki Shimizu,Takeshi Ogihara,Yoshifumi Tamura,Yuko Sakurai,Risako Yamamoto,Tomoya Mita,Yoshio Fujitani,Hiroshi Fukuda,Koji Nomoto,Takuya Takahashi,Takashi Asahara,Takahisa Hirose,Satoru Nagata,Yuichiro Yamashiro,Hirotaka Watada +22 more
TL;DR: This is the first report of gut dysbiosis in Japanese patients with type 2 diabetes as assessed by RT-qPCR, and the high rate of gut bacteria in the circulation suggests translocation of bacteria from the gut to the bloodstream.
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Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease.
Hiromasa Takaishi,Takahiro Matsuki,Atsushi Nakazawa,Toshihiko Takada,Shoichi Kado,Takashi Asahara,Nobuhiko Kamada,Atsushi Sakuraba,Tomoharu Yajima,Hajime Higuchi,Nagamu Inoue,Haruhiko Ogata,Yasushi Iwao,Koji Nomoto,Ryuichiro Tanaka,Toshifumi Hibi +15 more
TL;DR: Findings indicate that IBD is not caused by a specific intestinal bacterial cluster or species and that disordered intestinal microflora could be involved in the pathogenesis of IBD.
Journal ArticleDOI
Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial.
Gen Sugawara,Masato Nagino,Hideki Nishio,Tomoki Ebata,Kenji Takagi,Takashi Asahara,Koji Nomoto,Yuji Nimura +7 more
TL;DR: Preoperative oral administration of synbiotics can enhance immune responses, attenuate systemic postoperative inflammatory responses, and improve intestinal microbial environment, and likely reduce postoperative infectious complications after hepatobiliary resection for biliary tract cancer.
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Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon
Seong Gyu Jeon,Hisako Kayama,Yoshiyasu Ueda,Takuya Takahashi,Takashi Asahara,Hirokazu Tsuji,Noriko M. Tsuji,Hiroshi Kiyono,Ji Su Ma,Takashi Kusu,Ryu Okumura,Hiromitsu Hara,Hiroki Yoshida,Masahiro Yamamoto,Koji Nomoto,Kiyoshi Takeda +15 more
TL;DR: It is demonstrated that B. breve prevents intestinal inflammation through the induction of intestinal IL-10-producing Tr1 cells in the large intestine through the TLR2/MyD88 pathway.