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Nobuhisa Ohno
Researcher at Toronto General Hospital
Publications - 18
Citations - 462
Nobuhisa Ohno is an academic researcher from Toronto General Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 7 publications receiving 446 citations. Previous affiliations of Nobuhisa Ohno include University of Western Ontario.
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Journal ArticleDOI
TIMP-3 Deficiency Leads to Dilated Cardiomyopathy
Paul W.M. Fedak,David Smookler,Zamaneh Kassiri,Nobuhisa Ohno,Kevin J. Leco,Subodh Verma,Donald A.G. Mickle,Katrina L Watson,Carlo V. Hojilla,William Cruz,Richard D. Weisel,Ren-Ke Li,Rama Khokha +12 more
TL;DR: Therapeutic restoration of myocardial TIMP-3 may provide a novel approach to limit cardiac remodeling and the progression to failure in patients with dilated cardiomyopathy.
Journal ArticleDOI
Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3.
Paul W.M. Fedak,Svetlana M. Altamentova,Richard D. Weisel,Nafiseh Nili,Nobuhisa Ohno,Subodh Verma,Tsu-Yee J. Lee,Chris G. Kiani,Donald A.G. Mickle,Bradley H. Strauss,Ren-Ke Li +10 more
TL;DR: TIMP-3 may contribute to the regulation of myocardial remodeling and its reduction may promote a transition from compensated to end-stage congestive heart failure.
Journal ArticleDOI
Cell Transplantation to Prevent Heart Failure: A Comparison of Cell Types
Takeshiro Fujii,Terrence M. Yau,Richard D. Weisel,Nobuhisa Ohno,Donald A.G. Mickle,Noritsugu Shiono,Tsukasa Ozawa,Keiji Matsubayashi,Ren-Ke Li +8 more
TL;DR: Transplantation of SMC, VHC, and SKC preserved ventricular function equivalent to the effects of an ACE inhibitor, and Muscle cell transplantation, but not ACE inhibitor therapy, continues to be effective later after cryoinjury.
Journal ArticleDOI
Cell transplantation preserves matrix homeostasis: a novel paracrine mechanism.
Paul W.M. Fedak,Paul E. Szmitko,Richard D. Weisel,Svetlana M. Altamentova,Nafiseh Nili,Nobuhisa Ohno,Subodh Verma,Subodh Verma,Shafie Fazel,Bradley H. Strauss,Ren-Ke Li +10 more
TL;DR: These data provide the first evidence that cell transplantation limits ventricular dilatation in the failing heart through a paracrine-mediated mechanism that preserves extracellular matrix homeostasis.
Journal ArticleDOI
Transplantation of cryopreserved muscle cells in dilated cardiomyopathy: effects on left ventricular geometry and function.
Nobuhisa Ohno,Paul W.M. Fedak,Richard D. Weisel,Donald A.G. Mickle,Takeshiro Fujii,Ren-Ke Li +5 more
TL;DR: Both cryopreserved vascular smooth muscle cells and skeletal myoblasts from cardiomyopathic donors formed a viable muscle-resembling tissue that prevented wall thinning, limited left ventricular dilatation, and preserved global systolic function in hamsters with a genetic dilatedCardiomyopathy.