N
Nobuo Shimma
Researcher at Hoffmann-La Roche
Publications - 92
Citations - 3268
Nobuo Shimma is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Alkyl & Capecitabine. The author has an hindex of 24, co-authored 92 publications receiving 3160 citations. Previous affiliations of Nobuo Shimma include Chugai Pharmaceutical Co..
Papers
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Journal ArticleDOI
Hispidospermidin, a novel phospholipase C inhibitor produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127. II. Isolation, characterization and structural elucidation.
Tatsuo Ohtsuka,Yoshiko Itezono,Noboru Nakayama,Akiko Sakai,Nobuo Shimma,Kazuteru Yokose,Haruo Seto +6 more
TL;DR: Hispidospermidin is a novel phospholipase C inhibitor produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127 that has been elucidated as a cage compound with a trimethylspermidine side chain based on various NMR studies, including 1H-1H COSY, HOHAHA, HMBC, COLOC and long range J C-H resolved 2D spectroscopy.
Patent
3-[4-(4-cyanophenyl)thiazol-2-y)]-1-(1h-1,2,4-triazol-1-yl)-butan-2-ol derivatives having antifungal activity
Tadakatsu Hayase,Shigeyasu Ichihara,Yoshiaki Isshiki,Pingli Liu,Jun Ohwada,Toshiya Sakai,Nobuo Shimma,Masao Tsukazaki,Isao Umeda,Toshikazu Yamazaki +9 more
TL;DR: Azole derivatives of formula (I) and the salts thereof can be used in the production of medicaments for treating fungal infections and mycoses as discussed by the authors, and they are a pharmaceutically acceptable anion.
Journal ArticleDOI
Cassette dosing approach and quantitative structure-pharmacokinetic relationship study of antifungal N-myristoyltransferase inhibitors.
Kiyoshi Hasegawa,Hidetoshi Shindoh,Yasuhiko Shiratori,Tatsuo Ohtsuka,Yuko Aoki,Shigeyasu Ichihara,Ikuo Horii,Nobuo Shimma +7 more
TL;DR: The QSPKR model obtained is predictive and simple, and would give a direction for designing new Nmt inhibitors having good PK profiles, and the number of rotational bonds (Rotlbonds).
Journal ArticleDOI
Penitricin, a new class of antibiotic produced by Penicillium aculeatum. III. Structural confirmation by chemical synthesis and biological activity.
TL;DR: A novel antibiotic, penitricin showing anti-Gram-negative activity, has been isolated from the culture filtrate of Penicillium aculeatum and its structure was determined as hydroxymethylcyclopropenone by chemical synthesis from propargyl alcohol.
Journal ArticleDOI
3D-QSAR study of antifungal N-myristoyltransferase inhibitors by comparative molecular surface analysis
TL;DR: The 3D-QSAR model has given additional information about the binding of a benzofuran inhibitor to Nmt and the resulting best model is significantly more predictive than the one with all chemical descriptors.