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Yoshiko Itezono
Researcher at Hoffmann-La Roche
Publications - 27
Citations - 669
Yoshiko Itezono is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Two-dimensional nuclear magnetic resonance spectroscopy & Thrombin. The author has an hindex of 15, co-authored 27 publications receiving 650 citations.
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Journal ArticleDOI
Structural determination of geometrical isomers of microcystins LR and RR from cyanobacteria by two-dimensional NMR spectroscopic techniques.
Ken-ichi Harada,Kiyoshi Ogawa,Kenji Matsuura,Hideaki Murata,Makoto Suzuki,Mariyo F. Watanabe,Yoshiko Itezono,Noboru Nakayama +7 more
TL;DR: A nondestructive method using a combination of three 2D NMR techniques, DQF-COSY (double quantum filter correlation spectroscopy), HMQC (1H-detected multiple quantum coherence), and HMBC (heteronuclear multiple bond correlation), were developed for structural determination of microcystins, toxic heptapeptides produced by cyanobacteria.
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Isolation of two toxic heptapeptide microcystins from an axenic strain of Microcystis aeruginosa, K-139.
Ken-ichi Harada,Kiyoshi Ogawa,Kenji Matsuura,Hidetoshi Nagai,Hideaki Murata,Makoto Suzuki,Yoshiko Itezono,Noboru Nakayama,Makoto Shirai,Masayasu Nakano +9 more
TL;DR: Two toxic heptapeptides were isolated from an axenic Microcystis aeruginosa strain using mainly a non-destructive NMR method and the structure of the major toxin was determined to be 7-desmethylmicrocystin LR which lacks an N-methyl group of the dehydroalanine moiety of microcyStin LR.
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Structure of a novel phospholipase C inhibitor, vinaxanthone (Ro 09-1450), produced by penicillium vinaceum
Masahiro Aoki,Yoshiko Itezono,Haruyoshi Shirai,Noboru Nakayama,Akiko Sakai,Yutaka Tanaka,Akiko Yamaguchi,Nobuo Shimma,Kazuteru Yokose,Haruo Seto +9 more
TL;DR: Vinaxanthone is a novel phospholipase C inhibitor produced by Penicillium vinaceum Gilman and about NR6815 as mentioned in this paper, which has been elucidated as a polycyclic xanthone with poly acidic functional groups based on various NMR studies.
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A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. I. Taxonomy, fermentation, isolation and structural elucidation.
Shoko Matsukuma,Tatsuo Ohtsuka,Kotaki Hiromichi,Haruyoshi Shirai,Takashi Sano,Kimihiro Watanabe,Noboru Nakayama,Yoshiko Itezono,Morio Fujiu,Nobuo Shimma,Kazuteru Yokose,Toru Okuda +11 more
TL;DR: A new series of antifungal antibiotics, Ro 09-1470 and its 6 congeners were isolated from the fermentation broth of Penicillium sp.
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Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp.
Tatsuo Ohtsuka,Tsutomu Kudoh,Nobuo Shimma,Kotaki Hiromichi,Noboru Nakayama,Yoshiko Itezono,Noriko Fujisaki,J. Watanabe,Kazuteru Yokose,Haruo Seto +9 more
TL;DR: Tetronothiodin is a potent and selective cholecystokinin type B (CCK-B) receptor antagonist produced by Streptomyces sp.