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Nomalie Jaya
Researcher at University of Arizona
Publications - 4
Citations - 595
Nomalie Jaya is an academic researcher from University of Arizona. The author has contributed to research in topics: Binding site & Structural biology. The author has an hindex of 4, co-authored 4 publications receiving 554 citations.
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Journal ArticleDOI
Quaternary dynamics and plasticity underlie small heat shock protein chaperone function
Florian Stengel,Andrew Baldwin,Alexander J. Painter,Nomalie Jaya,Eman Basha,Lewis E. Kay,Elizabeth Vierling,Carol V. Robinson,Justin L. P. Benesch +8 more
TL;DR: It is found that thermally regulated quaternary dynamics of the sHSP establish and maintain the plasticity of the system, which extends the paradigm that intrinsic dynamics are crucial to protein function to include equilibrium fluctuations in quaternARY structure, and suggests they are integral to the s HSPs’ role in the cellular protein homeostasis network.
Journal ArticleDOI
Substrate binding site flexibility of the small heat shock protein molecular chaperones
TL;DR: The results support a model in which the intrinsically-disordered N-terminal arm can present diverse geometries of interaction sites, which is likely critical for the ability of sHSPs to protect efficiently many different substrates.
Journal ArticleDOI
Dissecting Heterogeneous Molecular Chaperone Complexes Using a Mass Spectrum Deconvolution Approach
Florian Stengel,Andrew Baldwin,Matthew F. Bush,Gillian R. Hilton,Hadi Lioe,Eman Basha,Eman Basha,Nomalie Jaya,Elizabeth Vierling,Justin L. P. Benesch +9 more
TL;DR: A nanoelectrospray mass spectrometry analysis algorithm is presented for estimating the distribution of stoichiometries comprising a polydisperse ensemble of oligomers and finds that binding is mass dependent, with the resultant complexes reflecting the native quaternary architecture of the target.
Journal ArticleDOI
Real-Time Monitoring of Protein Complexes Reveals their Quaternary Organization and Dynamics
Alexander J. Painter,Nomalie Jaya,Eman Basha,Elizabeth Vierling,Carol V. Robinson,Justin L. P. Benesch +5 more
TL;DR: This work investigates the properties of two small heat shock proteins and finds that these proteins exist as dodecamers composed of dimeric building blocks, and shows that they exchange dimers on the timescale of minutes, with the rate of exchange being strongly temperature dependent.