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Noor Gammoh
Researcher at University of Edinburgh
Publications - 13
Citations - 616
Noor Gammoh is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Autophagy & Autophagosome. The author has an hindex of 9, co-authored 13 publications receiving 407 citations. Previous affiliations of Noor Gammoh include Edinburgh Cancer Research Centre.
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Journal ArticleDOI
The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes
Katherine Fletcher,Rachel Ulferts,Elise Jacquin,Talitha Veith,Noor Gammoh,Julia M Arasteh,Ulrike Mayer,Simon R. Carding,Thomas Wileman,Rupert Beale,Oliver Florey +10 more
TL;DR: It is shown that the WD repeat‐containing C‐terminal domain (WD40 CTD) of ATG16L1 is essential for LC3 recruitment to endolysosomal membranes during non‐canonical autophagy, but dispensable for canonicalAutophagy.
Journal ArticleDOI
Suppression of autophagy impedes glioblastoma development and induces senescence
Noor Gammoh,Jane Fraser,Cindy Puente,Heather M. Syred,Helen Kang,Tatsuya Ozawa,Du Lam,Juan Carlos Acosta,Andrew J. Finch,Eric C. Holland,Xuejun Jiang +10 more
TL;DR: Inhibition of autophagy strongly reduced glioblastoma development, demonstrating its critical role in promoting tumor formation and is a promising therapeutic target for gliOBlastoma treatment.
Journal ArticleDOI
Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy
Leo J. Dudley,Ainara G. Cabodevilla,Agata N. Makar,Martin Sztacho,Tim Michelberger,Joseph A. Marsh,Douglas R. Houston,Sascha Martens,Xuejun Jiang,Noor Gammoh +9 more
TL;DR: The findings indicate that ATG16L1 harbours an intrinsic ability to bind lipids that plays an essential role during LC3 lipidation and autophagosome maturation.
Journal ArticleDOI
Targeting of early endosomes by autophagy facilitates EGFR recycling and signalling.
Jane Fraser,Joanne E Simpson,Rosa Fontana,Chieko Kishi-Itakura,Nicholas T. Ktistakis,Noor Gammoh +5 more
TL;DR: It is found that the ablation of autophagy‐essential players disrupts EGF‐induced endocytic trafficking of EGFR, which reduces EGFR recycling to the plasma membrane and compromises downstream signalling and cell survival.
Journal ArticleDOI
MicroRNA-26a promotes anoikis in human hepatocellular carcinoma cells by targeting alpha5 integrin.
Xiang Zhang,Shu-Li Cheng,Ka Bian,Lei Wang,Xiao Zhang,Bo Yan,Lin-Tao Jia,Jing Zhao,Noor Gammoh,Angang Yang,Rui Zhang +10 more
TL;DR: It is discovered that miR-26a promotes anoikis of HCC cells both in vitro and in vivo and is a potential therapeutic target for the treatment of metastatic HCC.