R
Rachel Ulferts
Researcher at Francis Crick Institute
Publications - 25
Citations - 1467
Rachel Ulferts is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Coronavirus & RNA. The author has an hindex of 9, co-authored 25 publications receiving 688 citations. Previous affiliations of Rachel Ulferts include University of Cambridge.
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Journal ArticleDOI
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Kevin W. Ng,Nikhil Faulkner,Georgina H. Cornish,Annachiara Rosa,Ruth Harvey,Saira Hussain,Rachel Ulferts,Christopher Earl,A.G. Wrobel,D.J. Benton,Chloe Roustan,William Bolland,Rachael Thompson,Ana Agua-Doce,Philip Hobson,Judith Heaney,Hannah Rickman,Stavroula Paraskevopoulou,Catherine F Houlihan,Kirsty Thomson,Emilie Sanchez,Gee Yen Shin,Moira J. Spyer,Dhira Joshi,Nicola O’Reilly,Philip A. Walker,Svend Kjaer,Andrew Riddell,Catherine Moore,Bethany R. Jebson,Meredyth G. Ll Wilkinson,Lucy R. Marshall,Elizabeth C. Rosser,Anna Radziszewska,Hannah Peckham,Coziana Ciurtin,Lucy R. Wedderburn,Rupert Beale,Charles Swanton,Sonia Gandhi,Brigitta Stockinger,John W. McCauley,Steve Gamblin,Laura E. McCoy,Peter Cherepanov,Eleni Nastouli,George Kassiotis,George Kassiotis +47 more
TL;DR: Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, preexisting humoral immunity was detected and antibodies targeting the S2 subunit were particularly prevalent in children and adolescents.
Journal ArticleDOI
The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes
Katherine Fletcher,Rachel Ulferts,Elise Jacquin,Talitha Veith,Noor Gammoh,Julia M Arasteh,Ulrike Mayer,Simon R. Carding,Thomas Wileman,Rupert Beale,Oliver Florey +10 more
TL;DR: It is shown that the WD repeat‐containing C‐terminal domain (WD40 CTD) of ATG16L1 is essential for LC3 recruitment to endolysosomal membranes during non‐canonical autophagy, but dispensable for canonicalAutophagy.
Journal ArticleDOI
SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity.
Annachiara Rosa,Valerie E. Pye,Carl Graham,Luke Muir,Jeffrey Seow,Kevin W. Ng,Nicola J. Cook,Chloe Rees-Spear,Eleanor Parker,Mariana Silva dos Santos,Carolina Rosadas,Alberto Susana,Hefin Rhys,Andrea Nans,Laura Masino,Chloe Roustan,Evangelos Christodoulou,Rachel Ulferts,A.G. Wrobel,Charlotte Eve Short,Michael Fertleman,Rogier W. Sanders,Rogier W. Sanders,Judith Heaney,Judith Heaney,Moira Spyer,Moira Spyer,Moira Spyer,Svend Kjaer,Andy Riddell,Michael H. Malim,Rupert Beale,James I. MacRae,Graham P. Taylor,Eleni Nastouli,Eleni Nastouli,Eleni Nastouli,Marit J. van Gils,Peter B. Rosenthal,Massimo Pizzato,Myra O. McClure,Richard S. Tedder,George Kassiotis,George Kassiotis,Laura E. McCoy,Katie J. Doores,Peter Cherepanov,Peter Cherepanov +47 more
TL;DR: In this article, the tetrapyrrole interaction pocket was mapped to a deep cleft on the spike N-terminal domain (NTD), which can be controlled by an allosteric mechanism that is regulated through recruitment of a metabolite.
Journal ArticleDOI
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
Joanne Durgan,Alf Håkon Lystad,Katherine Sloan,Sven R. Carlsson,Michael A Wilson,Elena Marcassa,Rachel Ulferts,Judith Webster,Andrea F. Lopez-Clavijo,Michael J.O. Wakelam,Rupert Beale,Anne Simonsen,David Oxley,Oliver Florey +13 more
TL;DR: In this article, the authors showed that all ATG8s can also undergo alternative lipidation to phosphatidylserine (PS) during CASM, induced pharmacologically, by LC3-associated phagocytosis or influenza A virus infection, in mammalian cells.
Journal ArticleDOI
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses.
Enzo Z. Poirier,Michael D. Buck,Probir Chakravarty,Joana Carvalho,Bruno Frederico,Ana Cardoso,Lyn Healy,Rachel Ulferts,Rupert Beale,Rupert Beale,Caetano Reis e Sousa +10 more
TL;DR: In this paper, the authors identified an isoform of Dicer, named antiviral Dicer (aviD), that protects tissue stem cells from RNA viruses by dicing viral double-stranded RNA to orchestrate antiviral RNAi.