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Norberto Leyva-García
Publications - 26
Citations - 289
Norberto Leyva-García is an academic researcher. The author has contributed to research in topics: Spinocerebellar ataxia & Population. The author has an hindex of 8, co-authored 22 publications receiving 234 citations.
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Journal ArticleDOI
Nanoparticle technology for treatment of Parkinson's disease: the role of surface phenomena in reaching the brain.
Gerardo Leyva-Gómez,Hernán Cortés,Jonathan J. Magaña,Norberto Leyva-García,David Quintanar-Guerrero,Benjamín Florán +5 more
TL;DR: This review provides an overview of technical aspects in the design of brain drug delivery of nanoparticles and an analysis of surface phenomena, a key aspect in the development of functional nanoparticles for Parkinson's disease.
Journal ArticleDOI
Analysis of CAG repeats in five SCA loci in Mexican population: epidemiological evidence of a SCA7 founder effect
Jonathan J. Magaña,Y. S. Tapia-Guerrero,Luis Velázquez-Pérez,César M Cerecedo-Zapata,M. Maldonado-Rodríguez,Joan Jano-Ito,Norberto Leyva-García,Rigoberto González-Piña,Emilio Martínez-Cruz,Oscar Hernández-Hernández,Bulmaro Cisneros +10 more
TL;DR: Genotyping of 300 healthy individuals from Mexican population and compiled data from different ethnicities showed discordant results concerning the hypothesis that SCA disease alleles arise by expansion of large normal alleles.
Journal ArticleDOI
A comprehensive clinical and genetic study of a large Mexican population with spinocerebellar ataxia type 7
Luis Velázquez-Pérez,César M Cerecedo-Zapata,Oscar Hernández-Hernández,Emilio Martínez-Cruz,Y. S. Tapia-Guerrero,Rigoberto González-Piña,J. Salas-Vargas,Roberto Rodríguez-Labrada,R. Gurrola-Betancourth,Norberto Leyva-García,Bulmaro Cisneros,Jonathan J. Magaña +11 more
TL;DR: Ataxia rating scales confirmed the critical role size of cytosine-adenine-guanine (CAG) repeat size on age at onset and disease severity, while analysis of CAG repeat instability showed that paternal rather than maternal transmission led to greater instability.
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Origin of the Spinocerebellar Ataxia Type 7 Gene Mutation in Mexican Population
Jonathan J. Magaña,Rocío Gómez,M. Maldonado-Rodríguez,M. Maldonado-Rodríguez,Luis Velázquez-Pérez,Y. S. Tapia-Guerrero,Hernán Cortés,Norberto Leyva-García,Oscar Hernández-Hernández,Bulmaro Cisneros +9 more
TL;DR: Genotyping using 17 short tandem repeat markers from the non-recombining region of the Y chromosome and phylogenetic relationship analysis revealed that Mexican patients possess the Western European ancestry, which might trace the SCA7 ancestral mutation to that world region.
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The relationship among IL-13, GSTP1, and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico.
Balam Muñoz,Jonathan J. Magaña,Israel Romero-Toledo,Evelyn Juárez-Pérez,Andrea López-Moya,Norberto Leyva-García,Celsa López-Campos,Víctor M. Dávila-Borja,Arnulfo Albores +8 more
TL;DR: No association among ETS exposure, asthma, and the studied polymorphisms was denoted by multivariate analysis of this population of children from Coahuila state in Northern Mexico.