Norio Ogawa

TL;DR: The double-edged synthesizing and oxidizing functions of tyrosinase in the dopaminergic system suggest its potential for application in the synthesis of DA, instead of TH in the degeneration of dopamine neurons, and in the normalization of abnormal DA turnover in long-term L-DOPA-treated Parkinson's disease patients.

TL;DR: The pole test appears to be useful in predicting the extent of the lesion to select a mouse in which the receptive fields of the dopaminergic cells are denervated, and shows that presynaptic neuroadaptations and behavioral recovery exist in this animal model.

TL;DR: It is suggested that MPTP-treated mice are a useful experimental model for the study of parkinsonism, and that the pole test using these animals is of value in the screening of anti-parkinsonian agents.

TL;DR: The results suggest that CD16+ monocytes and synovial tissue macrophages with high TLR-2 expression may be induced by M-CSF and IL-10, and their production of TNFalpha could be simulated by endogenous TLR ligands such as Hsp60 and FcgammaRIIIA ligation by small immune complexes in RA joints.

TL;DR: In vitro free radical scavenging and antioxidant activities of ropinirole, a non-ergot DA agonist, as well as its glutathione, catalase and superoxide dismutase activating effects and neuroprotective effect in vivo are assessed to indicate that activation of GSH, catAlase and SOD mediated via DA D2 receptors may be the principal mechanism of neuroprotection by roPinirole.