N
Norio Ohyabu
Researcher at Nagoya University
Publications - 14
Citations - 477
Norio Ohyabu is an academic researcher from Nagoya University. The author has contributed to research in topics: Overman rearrangement & Enantioselective synthesis. The author has an hindex of 7, co-authored 13 publications receiving 444 citations.
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First Asymmetric Total Synthesis of Tetrodotoxin
TL;DR: This work has achieved the first asymmetric total synthesis from 2-acetoxy-tri-O-acetyl-d-glucal as a chiral starting material and selected the protective groups to accomplish the total synthesis of tetrodotoxin in an enantiomerically pure form.
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Improved Conditions for Facile Overman Rearrangement(1)
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Synthesis of a common key intermediate for (−)-tetrodotoxin and its analogs
TL;DR: In this article, a key intermediate for tetrodotoxin and its analogs such as (−)-5,11-dideoxytetrodoxin was stereoselectively synthesized from a chiral starting material, levoglucosenone, via Diels-Alder reaction and the Overman rearrangement as key steps.
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Stereocontrolled Synthesis of (-)-5,11-Dideoxytetrodotoxin.
TL;DR: The first asymmetric synthesis of the simple tetrodotoxin analogue, 5,11-dideoxytetrodoxin (3), was achieved in this article. But the synthesis was performed at position C8 of the key intermediate, and stereoselective elaboration of the vinyl group gave alpha-hydroxylactone.
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Stereocontrolled synthesis of (−)-5,11-dideoxytetrodotoxin
TL;DR: The first asymmetric synthesis of the simple tetrodot toxin analogue, 5,11-dideoxytetrodotoxin analogue, was achieved and was transformed into the title compound through a new guanidylation method.