N
Noriyuki Kasahara
Researcher at University of California, San Francisco
Publications - 186
Citations - 5938
Noriyuki Kasahara is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Genetic enhancement & Gene delivery. The author has an hindex of 41, co-authored 180 publications receiving 5496 citations. Previous affiliations of Noriyuki Kasahara include University of Miami & Memorial Sloan Kettering Cancer Center.
Papers
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Journal ArticleDOI
Tissue-specific targeting of retroviral vectors through ligand-receptor interactions.
TL;DR: A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus, and this murine virus became several times more infectious for murine cells bearing the erythroietin receptor.
Patent
Methods and compositions for targeting specific tissue
Yuet Wai Kan,Noriyuki Kasahara +1 more
TL;DR: In this paper, a vehicle for preferentially targeting the delivery of a substance to a sub-population of mammalian cells is described, which includes a targeting moiety capable of associating with or forming an envelope defining a compartment that contains the substance to be delivered to the subpopulation of cells.
Journal ArticleDOI
Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa.
Mei Chen,Noriyuki Kasahara,Douglas R. Keene,Lawrence S. Chan,Warren K. Hoeffler,Deborah Ruth Finlay,Maria Barcova,Paula M. Cannon,Constance Mazurek,David T. Woodley +9 more
TL;DR: It is demonstrated that it is possible to restore type VII collagen gene expression in RDEB skin in vivo using a self-inactivating minimal lentivirus-based vector and to regenerate human skin on immune-deficient mice.
Journal ArticleDOI
Ligand-directed retroviral targeting of human breast cancer cells.
TL;DR: The feasibility of designing retroviral vectors that can target human breast cancer cells with characteristic receptors via ligand-receptor interaction was explored and the ecotropic Moloney murine leukemia virus envelope was modified by insertion of sequences encoding human heregulin.
Journal ArticleDOI
L1 retrotransposition in nondividing and primary human somatic cells
Shuji Kubo,Maria del Carmen Seleme,Harris S. Soifer,José Luis Garcia Perez,John V. Moran,Haig H. Kazazian,Noriyuki Kasahara +6 more
TL;DR: Data indicate that L1 retrotransposition can occur in nondividing somatic cells and shows that the expression of a highly active human L1 element from an adenovirus-L1 hybrid vector can be suppressed by the reverse transcriptase inhibitor 3'-azido-3'-deoxythymidine.