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Paula M. Cannon
Researcher at University of Southern California
Publications - 98
Citations - 6110
Paula M. Cannon is an academic researcher from University of Southern California. The author has contributed to research in topics: Genome editing & Murine leukemia virus. The author has an hindex of 40, co-authored 95 publications receiving 5526 citations. Previous affiliations of Paula M. Cannon include University of Oxford & Children's Hospital Los Angeles.
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Journal ArticleDOI
A transient three-plasmid expression system for the production of high titer retroviral vectors
Yuko Soneoka,Paula M. Cannon,Emma E. Ramsdale,J C Griffiths,Gaetano Romano,Susan M. Kingsman,Alan J. Kingsman +6 more
TL;DR: A series of MLV-based retroviral vectors and packaging components expressed from the CMV promoter and carried on plasmids containing SV40 origins of replication that achieved helper-free viral stocks of approximately 10(7) infectious units/ml by 48 h after transient co-transfection with the three plasmid components.
Journal ArticleDOI
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
Nathalia Holt,Jianbin Wang,Kenneth Kim,Geoffrey Friedman,Xingchao Wang,Vanessa Taupin,Donald B. Kohn,Philip D. Gregory,Michael C. Holmes,Paula M. Cannon +9 more
TL;DR: The demonstration that a minority of CCR5−/− HSPCs can populate an infected animal with HIV-1-resistant, CCR4+/− progeny supports the use of ZFN-modified autologous hematopoietic stem cells as a clinical approach to treating HIV- 1.
Journal ArticleDOI
International AIDS Society global scientific strategy: towards an HIV cure 2016
Steven G. Deeks,Sharon R Lewin,Anna Laura Ross,Jintanat Ananworanich,Monsef Benkirane,Paula M. Cannon,Nicolas Chomont,Daniel C. Douek,Jeffrey D. Lifson,Ying-Ru Lo,Daniel R. Kuritzkes,David M. Margolis,John W. Mellors,Deborah Persaud,Joseph D. Tucker,Françoise Barré-Sinoussi,Galit Alter,Judith D. Auerbach,Brigitte Autran,Dan H. Barouch,Georg M. N. Behrens,Marina Cavazzana,Zhiwei Chen,Éric A. Cohen,Giulio Maria Corbelli,Serge Eholié,Nir Eyal,Sarah Fidler,Laurindo Garcia,Cynthia I. Grossman,Gail E. Henderson,Timothy J. Henrich,Richard Jefferys,Hans-Peter Kiem,Joseph M. McCune,Keymanthri Moodley,Peter A. Newman,Monique Nijhuis,Moses Supercharger Nsubuga,Melanie Ott,Sarah Palmer,Douglas D. Richman,Asier Sáez-Cirión,Matthew G.F. Sharp,Janet M. Siliciano,Guido Silvestri,Jerome Amir Singh,Bruno Spire,Jeff Taylor,Martin Tolstrup,Susana T. Valente,Jan van Lunzen,Rochelle P. Walensky,Ira B. Wilson,Jerome A. Zack +54 more
TL;DR: A group of international experts to develop a scientific strategy for research towards an HIV cure summarized the group's strategy in this Perspective.
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AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges
Matthew R. Gardner,Lisa M. Kattenhorn,Hema R. Kondur,Markus von Schaewen,Tatyana Dorfman,Jessica J. Chiang,Kevin G. Haworth,Julie M. Decker,Michael D. Alpert,Charles C. Bailey,Ernest S. Neale,Christoph H. Fellinger,Vinita R. Joshi,Sebastian P. Fuchs,José M. Martinez-Navio,Brian D. Quinlan,Annie Y. Yao,Hugo Mouquet,Jason Gorman,Baoshan Zhang,Pascal Poignard,Michel C. Nussenzweig,Dennis R. Burton,Peter D. Kwong,Michael Piatak,Jeffrey D. Lifson,Guangping Gao,Ronald C. Desrosiers,David T. Evans,Beatrice H. Hahn,Alexander Ploss,Paula M. Cannon,Michael S. Seaman,Michael Farzan +33 more
TL;DR: It is shown that AAV-delivered eCD4-Ig can function like an effective HIV-1 vaccine and is more potent than the best bNAbs and also much broader than any bNAb.
Journal ArticleDOI
Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors
Jianbin Wang,Colin M. Exline,Joshua J. DeClercq,G. Nicholas Llewellyn,Samuel B. Hayward,Patrick Li,David A. Shivak,Richard T. Surosky,Philip D. Gregory,Michael C. Holmes,Paula M. Cannon +10 more
TL;DR: Combining electroporation of zinc finger nuclease (ZFN) mRNA with donor template delivery by adeno-associated virus (AAV) serotype 6 vectors directs efficient genome editing in HSPCs, achieving site-specific insertion of a GFP cassette at the CCR5 and AAVS1 loci.