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Nynke M. S. van den Akker
Researcher at Maastricht University
Publications - 28
Citations - 1008
Nynke M. S. van den Akker is an academic researcher from Maastricht University. The author has contributed to research in topics: Monocyte & Inflammation. The author has an hindex of 15, co-authored 25 publications receiving 863 citations. Previous affiliations of Nynke M. S. van den Akker include University of Münster & Leiden University Medical Center.
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Journal ArticleDOI
Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development.
Heleen Lie-Venema,Nynke M. S. van den Akker,Noortje A.M. Bax,Elizabeth M. Winter,Saskia Maas,Tuija Kekarainen,Rob C. Hoeben,Marco C. DeRuiter,Robert E. Poelmann,Adriana C. Gittenberger-de Groot +9 more
TL;DR: A role for EPDCs in cardiac looping is proposed, and their contribution to the development of the valves and myocardial architecture is emphasized, and congenital heart anomalies that might be caused primarily by an epicardial developmental defect are focused on.
Journal ArticleDOI
Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis
Martin Schmitt,Remco T. A. Megens,Alma Zernecke,Kiril Bidzhekov,Nynke M. S. van den Akker,Timo Rademakers,Marc A. M. J. van Zandvoort,Tilman M. Hackeng,Rory R. Koenen,Christian Weber +9 more
TL;DR: This paper showed that impaired JAM-A expression in endothelial cells reduced mononuclear cell recruitment into the arterial wall and limited atherosclerotic lesion formation in hyperlipidemic mice.
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Extracellular Vesicles Work as a Functional Inflammatory Mediator Between Vascular Endothelial Cells and Immune Cells.
Baharak Hosseinkhani,Sören Kuypers,Nynke M. S. van den Akker,Daniel G. M. Molin,Luc Michiels +4 more
TL;DR: It is proved that the EV released from inflamed EC were enriched with a cocktail of inflammatory markers, chemokines, and cytokines which are able to establish a targeted cross-talk between EC and monocytes and reprogramming them toward a pro- or anti-inflammatory phenotypes.
Journal ArticleDOI
Coronary Artery and Orifice Development Is Associated With Proper Timing of Epicardial Outgrowth and Correlated Fas Ligand Associated Apoptosis Patterns
Ismail Eralp,Heleen Lie-Venema,Marco C. DeRuiter,Nynke M. S. van den Akker,Ad J.J.C. Bogers,Monica M.T. Mentink,Robert E. Poelmann,Adriana C. Gittenberger-de Groot +7 more
TL;DR: In the absence of proper timing of epicardial outgrowth, myocardial development and vascularization are disturbed and apoptosis in the peritruncal region is diminished, which leads to defective or absent connections of the coronary system to the systemic circulation.
Journal ArticleDOI
The alternatively spliced anti-angiogenic family of VEGF isoforms VEGFxxxb in human kidney development.
Heather S. Bevan,Nynke M. S. van den Akker,Yan Qiu,Japke A.E. Polman,Rebecca R. Foster,Justin Yem,Ali Nishikawa,Simon C. Satchell,Steven J. Harper,Adriana C. Gittenberger-de Groot,David O. Bates +10 more
TL;DR: The results show that the anti-angiogenic VEGFxxxb isoforms are highly expressed in adult and developing renal cortex, and suggest that the VEGfxxxb family plays a role in glomerular maturation and podocyte protection by regulating the pro-angIogenic pro-permeability properties of VEGFs.