O
O. Franssen
Researcher at Utrecht University
Publications - 12
Citations - 1240
O. Franssen is an academic researcher from Utrecht University. The author has contributed to research in topics: Dextran & Self-healing hydrogels. The author has an hindex of 11, co-authored 12 publications receiving 1194 citations.
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Journal ArticleDOI
Synthesis, characterization, and polymerization of glycidyl methacrylate derivatized dextran
W. N. E. Van Dijk-Wolthuis,O. Franssen,Herre Talsma,M.J. van Steenbergen,J. J. Kettenes-van den Bosch,Wim E. Hennink +5 more
TL;DR: Glycidyl methacrylate derivatized dextran (dex-GMA) was synthesized by coupling of GMA to dextrans in the presence of 4-(N,N-dimethylamino)pyridine using DMSO as an aprotic solvent and characterized by GPC, FTIR, and NMR as discussed by the authors.
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Degradable dextran hydrogels: controlled release of a model protein from cylinders and microspheres.
TL;DR: This paper shows that the release of IgG from dex-HEMA hydrogels can be modulated by the composition (water content and DS) and the geometry of the gel (microspheres versus macroscopic gels).
Journal ArticleDOI
A novel preparation method for polymeric microparticles without the use of organic solvents
O. Franssen,Wim E. Hennink +1 more
TL;DR: In this paper, a novel emulsion technique based on polymer-polymer immiscibility in aqueous solutions was used for the preparation of well-defined microparticles differing in size, morphology and chemical composition.
Journal ArticleDOI
Dextran hydrogels for the controlled release of proteins
TL;DR: It was shown by FTIR analysis that by a proper selection of the polymerization conditions, hydrogels could be obtained in which more than 95% of the methacrylate groups had reacted within 20 min and was dependent on the amount of dextranase in the gel.
Journal ArticleDOI
The Preparation of Dextran Microspheres in an All-Aqueous System: Effect of the Formulation Parameters on Particle Characteristics
TL;DR: Particle characteristics of dextran microspheres prepared in an all-aqueous system, among which the size and initial water content, can be tailored by adjusting the formulation parameters, are investigated.