O. Khorram

TL;DR: The results indicate that NPY may have central effects on neuronal release of GnRH, and that ovarian factors are critical in the directional mode of these NPY actions.

TL;DR: NPY has direct effects on both the hypothalamus and pituitary to modulate the the activities of GnRH neurons and gonadotropes in intact and ovariectomized rabbits, suggesting that GnRH and gonads response to NPY exposure is determined by ovarian factors.

TL;DR: The results suggest that the high circulating levels of GH during the late prenatal and early neonatal periods are maintained by a combination of factors including the release of a hypothalamic peptidergic GH-releasing factor, the relative insensitivity of the pituitary to somatostatin, and changes in the relative size of storage vs. releasable pools ofGH during development.

TL;DR: The results indicate that AVP is involved in induction of ACTH and LH release during stress and the inhibitory action of the AVP antiserum on ACTH release may be mediated intrahypothalamically by blocking the stimulatory action of AVP on corticotropin-releasing factor (CRF) neurons and/or also in part by direct blockade of the stimulating action of vasopressin on the pituitary.

TL;DR: The results are interpreted to mean that at the higher dose, sufficient LHRH reached the site of origin of the hypophyseal portal vessels in the median eminence so that it diffused into portal vessels and was delivered to the gonadotrophs to induce LH release, and the lower dose provided sufficient hypothalamic concentrations of the peptide to suppress the discharge of the L HRH neurons, thereby leading to a decline in plasma LH.