O
Odile Dechy-Cabaret
Researcher at Centre national de la recherche scientifique
Publications - 26
Citations - 3287
Odile Dechy-Cabaret is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Aminoquinoline & Artemisinin. The author has an hindex of 15, co-authored 26 publications receiving 3069 citations. Previous affiliations of Odile Dechy-Cabaret include Paul Sabatier University & University of Toulouse.
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Controlled ring-opening polymerization of lactide and glycolide.
TL;DR: This work focuses on the characterization of the phytochemical components of Lactide ROP and their role in the regulation of cell reprograming.
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From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs.
TL;DR: Some possible ways for discovery of new drugs, especially the design of trioxaquines, new active molecules recently patented that have been prepared by covalent attachment of a trioxane residue having alkylating ability to a quinoline moiety known to easily penetrate within infected erythrocytes, are presented.
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Trioxaquines Are New Antimalarial Agents Active on All Erythrocytic Forms, Including Gametocytes
Françoise Benoit-Vical,Joël Lelièvre,Antoine Berry,Caroline Deymier,Odile Dechy-Cabaret,Jérôme Cazelles,Christophe Loup,Anne Robert,Jean-François Magnaval,Bernard Meunier +9 more
TL;DR: The present study confirms the absence of toxicity of this trioxaquine DU1302 on cell lines and in a mice model and exhibits potent activity against gametocytes, the form transmitted by mosquitoes, as killing of the gametocyte is essential to limit the spread of malaria.
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Preparation and antimalarial activities of "trioxaquines", new modular molecules with a trioxane skeleton linked to a 4-aminoquinoline.
TL;DR: This strategy, which can be characterized as a “covalent bitherapy”, allowed us to obtain modular molecules with high antimalarial activity in vitro either on chloroquine sensitive or onchloroquine resistant Plasmodium falciparum strains.
Journal ArticleDOI
Synthesis and antimalarial activity of trioxaquine derivatives.
Odile Dechy-Cabaret,Françoise Benoit-Vical,Christophe Loup,Anne Robert,Heinz Gornitzka,Anne Bonhoure,Henri Vial,Jean-François Magnaval,Jean-Paul Séguéla,Bernard Meunier +9 more
TL;DR: Trioxaquines are dual molecules that contain a trioxane motif linked to an aminoquinoline entity, and trioxaquine cis-15 (DU1302 c), prepared from alpha-terpinene, showed efficient antimalarial activity in vitro on both sensitive and resistant strains of Plasmodium falciparum.