F
Françoise Benoit-Vical
Researcher at University of Toulouse
Publications - 104
Citations - 6601
Françoise Benoit-Vical is an academic researcher from University of Toulouse. The author has contributed to research in topics: Plasmodium falciparum & Artemisinin. The author has an hindex of 37, co-authored 101 publications receiving 5789 citations. Previous affiliations of Françoise Benoit-Vical include National Polytechnic Institute of Toulouse & French Institute of Health and Medical Research.
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Journal ArticleDOI
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Frédéric Ariey,Benoit Witkowski,Chanaki Amaratunga,Johann Beghain,Anne-Claire Langlois,Nimol Khim,Saorin Kim,Valentine Duru,Christiane Bouchier,Laurence Ma,Pharath Lim,Rithea Leang,Socheat Duong,Sokunthea Sreng,Seila Suon,Char Meng Chuor,Denis Mey Bout,Sandie Menard,William O. Rogers,Blaise Genton,Thierry Fandeur,Olivo Miotto,Pascal Ringwald,Jacques Le Bras,Antoine Berry,Jean Christophe Barale,Rick M. Fairhurst,Françoise Benoit-Vical,Odile Mercereau-Puijalon,Didier Menard +29 more
TL;DR: Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance.
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K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
Judith Straimer,Nina F. Gnädig,Benoit Witkowski,Chanaki Amaratunga,Valentine Duru,Arba Pramundita Ramadani,Arba Pramundita Ramadani,Mélanie Dacheux,Nimol Khim,Lei Zhang,Stephen Lam,Philip D. Gregory,Fyodor D. Urnov,Odile Mercereau-Puijalon,Françoise Benoit-Vical,Françoise Benoit-Vical,Rick M. Fairhurst,Didier Menard,David A. Fidock +18 more
TL;DR: The data provide a conclusive rationale for worldwide K13-propeller sequencing to identify and eliminate artemisinin-resistant parasites and imperils efforts to reduce the global malaria burden.
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Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism
Benoit Witkowski,Joël Lelièvre,María J. López Barragán,Victor Laurent,Xin-zhuan Su,Antoine Berry,Antoine Berry,Françoise Benoit-Vical +7 more
TL;DR: In this paper, the authors showed that drug pressure could induce a subpopulation of ring stages into developmental arrest, which can explain the ART tolerance in P. falciparum.
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Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia
Benoit Witkowski,Nimol Khim,Pheaktra Chim,Saorin Kim,Sopheakvatey Ke,Nimol Kloeung,Sophie Chy,Socheat Duong,Rithea Leang,Pascal Ringwald,Arjen M. Dondorp,Rupam Tripura,Françoise Benoit-Vical,Antoine Berry,Olivier Gorgette,Frédéric Ariey,Jean-Christophe Barale,Odile Mercereau-Puijalon,Didier Menard +18 more
TL;DR: The reduced susceptibility to artemisinin in Pailin appears to be associated with an altered in vitro phenotype of ring stages from Pailsin in the RSA, which is associated with a clear-cut geographic dichotomy.
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Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species
Clotilde Ribaut,Antoine Berry,Séverine Chevalley,Karine Reybier,Isabelle Morlais,Daniel Parzy,Françoise Nepveu,Françoise Benoit-Vical,Françoise Benoit-Vical,Alexis Valentin +9 more
TL;DR: An adaptation of magnetic MACS® columns for the purification of human Plasmodium species is presented and was useful for the concentration/purification of either schizonts or gametocytes.