O
Oleg R. Malyshev
Publications - 3
Citations - 162
Oleg R. Malyshev is an academic researcher. The author has contributed to research in topics: Jurkat cells & Microtubule. The author has an hindex of 3, co-authored 3 publications receiving 138 citations.
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Polyalkoxy substituted 4H-chromenes: synthesis by domino reaction and anticancer activity.
Anatoliy M. Shestopalov,Yuri M. Litvinov,Lyudmila A. Rodinovskaya,Oleg R. Malyshev,Marina N. Semenova,Victor V. Semenov +5 more
Abstract: A series of 4H-chromenes containing various modifications in the ring B and polyalkoxy substituents in the ring E has been synthesized by Knoevenagel–Michael–hetero-Thorpe–Ziegler three-component d...
Journal ArticleDOI
Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays.
Marina N. Semenova,Alex S. Kiselyov,Dmitry V. Tsyganov,Leonid D. Konyushkin,S. I. Firgang,Roman V. Semenov,Oleg R. Malyshev,Mikhail M. Raihstat,Fabian Fuchs,Anne Stielow,Margareta Lantow,Margareta Lantow,Alex Philchenkov,M P Zavelevich,Nikolay S. Zefirov,Sergei A. Kuznetsov,Victor V. Semenov +16 more
TL;DR: Cytotoxic effects of selected molecules were further confirmed and evaluated by conventional assays with A549 and Jurkat human leukemic T-cell lines including cell growth inhibition, cell cycle arrest, cellular microtubule disruption, and induction of apoptosis.
Journal ArticleDOI
Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay.
Marina N. Semenova,Dmitry V. Tsyganov,Oleg R. Malyshev,Oleg V. Ershov,Ivan N. Bardasov,Roman V. Semenov,Alex S. Kiselyov,Victor V. Semenov +7 more
TL;DR: A series of polyalkoxy substituted 7-hydroxy- and 7-methoxy-4-aryl-4H-chromenes evaluated using the sea urchin embryo model yielded several compounds exhibiting potent antimitotic microtubule destabilizing activity.