Journal ArticleDOI
Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay.
Marina N. Semenova,Dmitry V. Tsyganov,Oleg R. Malyshev,Oleg V. Ershov,Ivan N. Bardasov,Roman V. Semenov,Alex S. Kiselyov,Victor V. Semenov +7 more
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TLDR
A series of polyalkoxy substituted 7-hydroxy- and 7-methoxy-4-aryl-4H-chromenes evaluated using the sea urchin embryo model yielded several compounds exhibiting potent antimitotic microtubule destabilizing activity.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2014-08-15. It has received 17 citations till now.read more
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Recent Advances in the Chemistry and Biology of Podophyllotoxins.
TL;DR: This Review provides a survey of podophyllotoxin and its analogues isolated from plants and summarizes recent developments in the elegant total chemical synthesis, structural modifications, biosynthesis, and biotransformation.
Journal ArticleDOI
Catalytic Asymmetric Addition of Meldrum’s Acid, Malononitrile, and 1,3‐Dicarbonyls to ortho‐Quinone Methides Generated In Situ Under Basic Conditions
Lorenzo Caruana,Martina Mondatori,Vasco Corti,Sara Morales,Sara Morales,Andrea Mazzanti,Mariafrancesca Fochi,Luca Bernardi +7 more
TL;DR: The use of mild Brønsted basic conditions for transiently generating o-QMs in catalytic asymmetric processes is unprecedented, and allows engaging productively in the reactions nucleophiles such as Meldrum's acid, malononitrile and 1,3-dicarbonyls.
Journal ArticleDOI
Triphenylphosphonium Cations of the Diterpenoid Isosteviol: Synthesis and Antimitotic Activity in a Sea Urchin Embryo Model
Irina Yu. Strobykina,Mayya G Belenok,Marina N. Semenova,Victor V. Semenov,Vasiliy M. Babaev,Il'dar Kh. Rizvanov,Vladimir F. Mironov,Vladimir E. Kataev +7 more
TL;DR: The results obtained using the sea urchin embryo model suggested that TPP conjugates of isosteviol induced mitotic spindle defects and mitotic arrest presumably by affecting mitochondrial DNA.
Journal ArticleDOI
The amino side chains do matter: chemoselectivity in the one-pot three-component synthesis of 2-amino-4H-chromenes by supramolecular catalysis with amino-appended β-cyclodextrins (ACDs) in water
Yufeng Ren,Bo Yang,Xiali Liao +2 more
TL;DR: In this study, the one-pot three-component synthesis of 2-amino-4H-chromenes was accomplished by supramolecular catalysis using a series of well-designed amino-appended β-cyclodextrins (ACDs) in water.
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Development of a Brønsted acid Al–MIL-53 metal–organic framework catalyst and its application in [4 + 2] cycloadditions
TL;DR: In this article, two Al-MIL-53 derived metal-organic frameworks (MOFs) were developed to serve as efficient heterogeneous Bronsted acid catalysts, which were successfully incorporated into the framework by post-synthetic modification (PSM) using commercially available reagents.
References
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Microtubule-binding agents: a dynamic field of cancer therapeutics
Charles Dumontet,Mary Ann Jordan +1 more
TL;DR: The screening of a range of botanical species and marine organisms has yielded promising new antitubulin agents with novel properties, and the three main objectives are enhanced tumour specificity, reduced neurotoxicity and insensitivity to chemoresistance mechanisms.
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Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
Raimond B. G. Ravelli,Benoît Gigant,Patrick A. Curmi,Isabelle Jourdain,Sylvie Lachkar,André Sobel,Marcel Knossow +6 more
TL;DR: Changes in the subunits of tubulin as it switches from its straight conformation to a curved one correlate with the loss of lateral contacts and provide a rationale for the rapid microtubule depolymerization characteristic of dynamic instability.
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An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site
TL;DR: The present review is a synopsis of compounds that have been reported in the past decade that have provided an increase in understanding of the actions of CBSIs.
Journal ArticleDOI
Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives
TL;DR: Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared from podophyLLotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity on several neoplastic cell lines.
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Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance
TL;DR: This review will focus on the different mechanisms of action of MTIs, potential factors related to resistance and tolerability, and will discuss the recent approval as well as the development of new antineoplastic agents.