O
Olga Dakhova
Researcher at Center for Cell and Gene Therapy
Publications - 40
Citations - 3812
Olga Dakhova is an academic researcher from Center for Cell and Gene Therapy. The author has contributed to research in topics: Antigen & Immunotherapy. The author has an hindex of 23, co-authored 37 publications receiving 2849 citations. Previous affiliations of Olga Dakhova include Baylor College of Medicine & Boston Children's Hospital.
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Journal ArticleDOI
Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma
Nabil Ahmed,Vita S. Brawley,Meenakshi Hegde,Catherine Robertson,Alexia Ghazi,Claudia Gerken,Enli Liu,Olga Dakhova,Aidin Ashoori,Amanda Corder,Tara Gray,Meng Fen Wu,Hao Liu,John Hicks,Nino Rainusso,Gianpietro Dotti,Zhuyong Mei,Bambi Grilley,Adrian P. Gee,Cliona M. Rooney,Malcolm K. Brenner,Helen E. Heslop,Winfried S. Wels,Lisa L. Wang,Peter M. Anderson,Stephen Gottschalk +25 more
TL;DR: This first evaluation of the safety and efficacy of HER2-CAR T cells in patients with cancer shows the cells can persist for 6 weeks without evident toxicities, setting the stage for studies that combine Her2- CAR T cells with other immunomodulatory approaches to enhance their expansion and persistence.
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Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
Yang Xu,Ming Zhang,Carlos A. Ramos,April G. Durett,Enli Liu,Olga Dakhova,Hao Liu,Chad J. Creighton,Adrian P. Gee,Helen E. Heslop,Cliona M. Rooney,Barbara Savoldo,Gianpietro Dotti +12 more
TL;DR: CD19-redirected T cells expanded ex vivo using IL-2, and found that their in vivo expansion only correlated with the frequency within the infused product of a CD8(+)CD45RA(+)CCR7(+) subset, whose phenotype is closest to "T-memory stem cells."
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CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma.
Andras Heczey,Chrystal U. Louis,Barbara Savoldo,Olga Dakhova,April G. Durett,Bambi Grilley,Hao Liu,Mengfeng F. Wu,Zhuyong Mei,Adrian P. Gee,Birju Mehta,Huimin Zhang,Nadia Mahmood,Haruko Tashiro,Helen E. Heslop,Gianpietro Dotti,Cliona M. Rooney,Malcolm K. Brenner +17 more
TL;DR: CARTs are safe, and Cy/Flu can further increase their expansion, which may have contributed to the modest early antitumor responses; the effect of these cells merits further study.
Journal ArticleDOI
Clinical and immunological responses after CD30-specific chimeric antigen receptor–redirected lymphocytes
Carlos A. Ramos,Brandon Ballard,Huimin Zhang,Olga Dakhova,Adrian P. Gee,Zhuyong Mei,Mrinalini Bilgi,Meng Fen Wu,Hao Liu,Bambi J. Grilley,Bambi J. Grilley,Catherine M. Bollard,Catherine M. Bollard,Bill H. Chang,Cliona M. Rooney,Malcolm K. Brenner,Malcolm K. Brenner,Helen E. Heslop,Helen E. Heslop,Gianpietro Dotti,Barbara Savoldo,Barbara Savoldo +21 more
TL;DR: CD30.CAR-Ts are safe and can lead to clinical responses in patients with HL and ALCL, indicating that further assessment of this therapy is warranted.
Journal ArticleDOI
Clinical responses with T lymphocytes targeting malignancy-associated κ light chains
Carlos A. Ramos,Barbara Savoldo,Vicky Torrano,Brandon Ballard,Huimin Zhang,Olga Dakhova,Enli Liu,George Carrum,Rammurti T. Kamble,Adrian P. Gee,Zhuyong Mei,Meng Fen Wu,Hao Liu,Bambi Grilley,Cliona M. Rooney,Malcolm K. Brenner,Helen E. Heslop,Gianpietro Dotti +17 more
TL;DR: A CAR that is specific for the κ light chain (κ.CART) and therefore recognizes κ-restricted cells and spares the normal B cells expressing the nontargeted λ light chain, thus potentially minimizing humoral immunity impairment.