O
Olga Gursky
Researcher at Boston University
Publications - 87
Citations - 2509
Olga Gursky is an academic researcher from Boston University. The author has contributed to research in topics: Lipoprotein & Apolipoprotein B. The author has an hindex of 29, co-authored 82 publications receiving 2251 citations. Previous affiliations of Olga Gursky include Brandeis University.
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Monitoring protein aggregation during thermal unfolding in circular dichroism experiments.
TL;DR: A convenient method to monitor in real time protein aggregation during thermal folding/ unfolding transition by recording turbidity or 90° light scattering data in circular dichroism (CD) spectroscopic experiments is proposed.
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Thermal unfolding of human high-density apolipoprotein A-1: implications for a lipid-free molten globular state.
Olga Gursky,David Atkinson +1 more
TL;DR: The results suggest that in vivo lipid binding by apoA-1 may be mediated via the molten globular apolipoprotein state in plasma under near-physiological conditions.
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Temperature-dependent β-sheet formation in β-amyloid Aβ1–40 peptide in water: uncoupling β-structure folding from aggregation
Olga Gursky,Sergei Aleshkov +1 more
TL;DR: In this paper, the role of temperature in the conversion of soluble Alzheimer's beta-amyloid peptide (Abeta) to insoluble beta-sheet rich aggregates was investigated.
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Human plasma high-density lipoproteins are stabilized by kinetic factors.
TL;DR: In this paper, the authors show that the particle stability has a kinetic rather than thermodynamic origin, and that a kinetic mechanism may facilitate structural integrity of the heterogeneous lipoprotein particles, slow their spontaneous interconversions, and thereby modulate lipiprotein lifetime and functions.
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The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain.
Elena S. Klimtchuk,Olga Gursky,Rupesh S. Patel,Kathryn L. Laporte,Lawreen H. Connors,Martha Skinner,David C. Seldin +6 more
TL;DR: A paradigm shift in AL fibrillogenesis is suggested and the role of C(L) region is suggested as a potential therapeutic target.