Olga Pavlova

TL;DR: This scientific review aims to summarize the current knowledge about neurobiological mechanisms of cognitive impairment in people with schizophrenia, depression, mild cognitive impairment and dementia (including Alzheimer’s disease).

TL;DR: Gender differences in the severity of clinical features are found—higher scores for delusions (Positive and Negative Syndrome Scale and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) in males and higher scores for depression, delusions, somatic concern, motor retardation, poor attention were found in females.

TL;DR: It is shown that patients with the TT allele (BDNF rs6265) had more severe impairments in frontal lobe function and a1-PI can serve as a marker for assessing the severity of frontal lobe damage in patients with frontal dementia.

TL;DR: In this article, the authors provide comprehensive evidence synthesis including all available up-to-date data about the prevalence of N-methyl D-aspartate receptor (NMDAR) antibodies (ABs) in psychotic patients in order to evaluate the clinical relevance of ABs as well as to specify potential explanations of the heterogeneity of the findings and determine areas for further research.

TL;DR: In this article , the authors discuss the potential contribution of protein illnesses in the development of psychopathologies and discuss the possible mechanisms of disruption to protein folding and aggregation in the cell: endoplasmic reticulum stress, dysfunction of chaperone proteins, altered mitochondrial function, and impaired autophagy processes.